E
Elina Ikonen
Researcher at Minerva Foundation Institute for Medical Research
Publications - 207
Citations - 26902
Elina Ikonen is an academic researcher from Minerva Foundation Institute for Medical Research. The author has contributed to research in topics: Endosome & Lipid droplet. The author has an hindex of 60, co-authored 197 publications receiving 24542 citations. Previous affiliations of Elina Ikonen include University of Helsinki & University of Geneva.
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Journal ArticleDOI
A Ceramide-Regulated Element in the Late Endosomal Protein LAPTM4B Controls Amino Acid Transporter Interaction.
Kecheng Zhou,Kecheng Zhou,Andrea Dichlberger,Andrea Dichlberger,Hector Martinez-Seara,Hector Martinez-Seara,Thomas K.M. Nyholm,Shiqian Li,Shiqian Li,Young Ah Kim,Ilpo Vattulainen,Ilpo Vattulainen,Elina Ikonen,Elina Ikonen,Tomas Blom,Tomas Blom +15 more
TL;DR: This work uncovers in atomistic detail the ceramide interaction of Lysosome Associated Protein Transmembrane 4B (LAPTM4B), implicated in ceramide-dependent cell death and autophagy, and its functional relevance in lysosomal nutrient signaling and mechanistic insights into how trans Membrane proteins sense and respond to ceramide.
Journal ArticleDOI
ORP2 couples LDL-cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P-2 exchange
Kohta Takahashi,Kohta Takahashi,Kristiina Kanerva,Kristiina Kanerva,Lauri Vanharanta,Lauri Vanharanta,Leonardo Almeida-Souza,Daniel Lietha,Vesa M. Olkkonen,Elina Ikonen,Elina Ikonen +10 more
TL;DR: In this paper, the authors employed auxin-inducible rapid degradation of oxysterol-binding protein-related protein 2 (ORP2/OSBPL2) to show that endogenous ORP2 mediates the transfer of LDL-derived cholesterol from late endosomes to focal adhesion kinase (FAK)-/integrin-positive recycling endosome in human cells.
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Polarized THG Microscopy Identifies Compositionally Different Lipid Droplets in Mammalian Cells
Godofredo Bautista,Simon G. Pfisterer,Simon G. Pfisterer,Mikko J. Huttunen,Mikko J. Huttunen,Sanjeev Ranjan,Sanjeev Ranjan,Kristiina Kanerva,Kristiina Kanerva,Elina Ikonen,Elina Ikonen,Martti Kauranen +11 more
TL;DR: Evidence is provided that polarized third-harmonic generation (THG) microscopy distinguishes between native TAG- and CE-enriched LDs in cells due to the different ordering of the two lipid species, and that with an increasing CE content, there is a rather sharp transition toward increased LD ordering.
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Endosomal Actin Remodeling by Coronin-1A Controls Lipoprotein Uptake and Degradation in Macrophages
TL;DR: Coro1A controls actin association with endocytic organelles, thereby negatively regulating endo-lysosomal delivery, degradation of modified lipoproteins and cholesterol deposition in macrophages.
Journal ArticleDOI
Severe neurodegenerative disease in brothers with homozygous mutation in POLR1A
Bülent Kara,Çiğdem Köroğlu,Karita Peltonen,Ruchama C. Steinberg,Hülya Maraş Genç,Maarit Hölttä-Vuori,Maarit Hölttä-Vuori,Ayse Guven,Kristiina Kanerva,Kristiina Kanerva,Tuğba Kotil,Seyhun Solakoglu,You Zhou,You Zhou,Vesa M. Olkkonen,Vesa M. Olkkonen,Elina Ikonen,Elina Ikonen,Marikki Laiho,Marikki Laiho,Aslıhan Tolun +20 more
TL;DR: These findings provide the first report showing a complex leukodystrophy associated with POLR1A, as a clinically unaffected sister of two brothers born to consanguineous parents was homozygous for the OSBPL11 variant.