E
Elina Ikonen
Researcher at Minerva Foundation Institute for Medical Research
Publications - 207
Citations - 26902
Elina Ikonen is an academic researcher from Minerva Foundation Institute for Medical Research. The author has contributed to research in topics: Endosome & Lipid droplet. The author has an hindex of 60, co-authored 197 publications receiving 24542 citations. Previous affiliations of Elina Ikonen include University of Helsinki & University of Geneva.
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Dissection of the molecular pathology of aspartylglucosaminuria provides the basis for dna diagnostics and future therapeutic interventions
TL;DR: Although AGU is a relatively rare disease, characterization of the AGU mutations and their cellular consequences have revealed highly interesting new phenomena in the biosynthesis of this lysosomal enzyme, some of which carry general biological significance.
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Specific subdomain localization of ER resident proteins and membrane contact sites resolved by electron microscopy.
TL;DR: In this article, a unique localization profile within the endoplasmic reticulum (ER) network was resolved for several resident ER proteins representing a broad range of functions associated with the ER using immuno-electron microscopy and calculation of a relative labeling index (RLI).
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Regression plane concept for analysing continuous cellular processes with machine learning.
Abel Szkalisity,Abel Szkalisity,Filippo Piccinini,Attila Beleon,Tamas Balassa,Istvan Gergely Varga,Ede Migh,Csaba Molnar,Lassi Paavolainen,Sanna Timonen,Indranil Banerjee,Elina Ikonen,Yohei Yamauchi,István Andó,Jaakko Peltonen,Jaakko Peltonen,Vilja Pietiäinen,Viktor Honti,Peter Horvath,Peter Horvath +19 more
TL;DR: In this article, the Regression Plane (RP) is introduced to describe and explore biological data in a continuous manner, which is a user-friendly discovery tool enabling class-free phenotypic supervised machine learning.
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Terminal deletion of chromosome 4p (4p16.3) shows a breakpoint between loci linked to Huntington disease.
TL;DR: The chromosomal breakpoint was analyzed by means of polymorphic DNA probes localized close to the tentative Huntington (HD) locus and deletes part of the chromosomal candidate regions for the HD locus.
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Language-Agnostic Reproducible Data Analysis Using Literate Programming
TL;DR: This case study demonstrates that with Lir, an array of tools can be combined in the same data analysis to improve efficiency, reproducibility, and ease of understanding.