E
Elina Ikonen
Researcher at Minerva Foundation Institute for Medical Research
Publications - 207
Citations - 26902
Elina Ikonen is an academic researcher from Minerva Foundation Institute for Medical Research. The author has contributed to research in topics: Endosome & Lipid droplet. The author has an hindex of 60, co-authored 197 publications receiving 24542 citations. Previous affiliations of Elina Ikonen include University of Helsinki & University of Geneva.
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Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases
King Faisal Yambire,Lorena Fernandez-Mosquera,Robert Steinfeld,Christiane Muehle,Elina Ikonen,Ira Milosevic,Nuno Raimundo +6 more
TL;DR: A transcriptional program is reported that represses mitochondrial biogenesis and function in lysosomal storage diseases Niemann-Pick type C (NPC) and acid sphingomyelinase deficiency (ASM), in patient cells and mouse tissues.
Journal ArticleDOI
Dissecting the Molecular Mechanisms of Polarized Membrane Traffic: Reconstitution of Three Transport Steps in Epithelial Cells Using Streptolysin-O Permeabilization
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Stromal CAVIN1 controls prostate cancer microenvironment and metastasis by modulating lipid distribution and inflammatory signaling
Jin Yih Low,W. Nathaniel Brennen,Alan K. Meeker,Elina Ikonen,Elina Ikonen,Brian W. Simons,Marikki Laiho +6 more
TL;DR: The data support the concept that stromal cells contribute to prostate cancer aggressiveness by modulating lipid content and inflammation in the tumor microenvironment byModulating tumor micro environment, lipid content, and inflammatory response.
Journal ArticleDOI
DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron depletion
Maeve Long,Alvaro Sanchez-Martinez,Marianna Longo,Fumi Suomi,Hans Stenlund,Annika I. Johansson,H. A. Ehsan,Veijo T. Salo,Lambert Montava-Garriga,Seyedehshima Naddafi,Elina Ikonen,Ian G. Ganley,Alexander J. Whitworth,Thomas G. McWilliams +13 more
TL;DR: Iron depletion is defined as a potent signal that rapidly reshapes metabolism and establishes an unexpected synergy between lipid homeostasis and mitophagy that safeguards cell and tissue integrity.
Journal ArticleDOI
Deletion of the 3'-untranslated region of aspartylglucosaminidase mRNA results in a lysosomal accumulation disease.
TL;DR: A homozygous 876-base pair deletion is reported, which removes the 3'-noncoding area but leaves the coding region of the AGA mRNA intact, which suggests that the deletion interferes with the translational efficiency in vivo and provides a unique model to pursue the biological significance of untranslated regions of human mRNAs.