Elinor Ng Eaton

TL;DR: Findings indicate that the establishment of the self-sustaining TGF-β and SDF-1 autocrine signaling gives rise to tumor-promoting CAF myofibroblasts during tumor progression, which may prove to be an attractive therapeutic target to block the evolution of tumor- Promoting CAFs.

TL;DR: It is shown that normal gland-reconstituting mammary stem cells residing in the basal layer of the mammary epithelium and breast TICs originating in the luminal layer exploit the paralogous EMT-TFs Slug and Snail, respectively, which induce distinct EMT programs.

TL;DR: In cultured cells, a cDNA clone of the cyclin D1 gene can contribute to cell transformation by complementing a defective adenovirus E1A oncogene, suggesting a similar role in tumor progression in vivo.

TL;DR: It is concluded that synthesis of the hTERT telomerase subunit represents the rate-limiting determinant of telomer enzyme activity in these cells and that this protein, once expressed, becomes part of the functional telomersase holoenzyme.

TL;DR: The cloning of the cyclin E promoter is reported and the identification of several putative E2F binding sites within the promoter sequence are reported, which suggest the operation of a positive-feedback loop in late G1 that functions to ensure continued cycle regulation and pRB inactivation.