T
Tsukasa Shibue
Researcher at Broad Institute
Publications - 34
Citations - 8714
Tsukasa Shibue is an academic researcher from Broad Institute. The author has contributed to research in topics: Focal adhesion & Cancer stem cell. The author has an hindex of 22, co-authored 33 publications receiving 7363 citations. Previous affiliations of Tsukasa Shibue include Massachusetts Institute of Technology & University of Tokyo.
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Journal ArticleDOI
Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis
Eri Oda,Rieko Ohki,Hideki Murasawa,Jiro Nemoto,Tsukasa Shibue,Toshiharu Yamashita,Takashi Tokino,Tadatsugu Taniguchi,Nobuyuki Tanaka +8 more
TL;DR: A previously unidentified pro-apoptotic gene, Noxa, which encodes a Bcl-2 homology 3 (BH3)-only member of the BCl-2 family of proteins may represent a mediator of p53-dependent apoptosis.
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EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
TL;DR: In this paper, the authors discuss the link between the epithelial-to-mesenchymal transition (EMT) and the cancer stem cell (CSC) phenotype and discuss how this knowledge can contribute to improvements in clinical practice.
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Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State
Wenjun Guo,Zuzana Keckesova,Joana Liu Donaher,Tsukasa Shibue,Verena Tischler,Ferenc Reinhardt,Shaul Shalev Itzkovitz,Aurelia Noske,Ursina Zürrer-Härdi,George W. Bell,Wai Leong Tam,Sendurai A. Mani,Alexander van Oudenaarden,Robert A. Weinberg +13 more
TL;DR: It is shown that coexpression of Slug and Sox9 promotes the tumorigenic and metastasis-seeding abilities of human breast cancer cells and is associated with poor patient survival, providing direct evidence that human breast cancers stem cells are controlled by key regulators similar to those operating in normal murine MaSCs.
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Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence.
Akinori Takaoka,Sumio Hayakawa,Hideyuki Yanai,Dagmar Stoiber,Dagmar Stoiber,Hideo Negishi,Hideaki Kikuchi,Shigeru Sasaki,Kohzoh Imai,Tsukasa Shibue,Kenya Honda,Tadatsugu Taniguchi +11 more
TL;DR: It is shown that transcription of the p53 gene is induced by IFN-α/β, accompanied by an increase in p53 protein level, and that p53 is critical for antiviral defence of the host.
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Distinct emt programs control normal mammary stem cells and tumour-initiating cells
Xin Ye,Wai Leong Tam,Wai Leong Tam,Tsukasa Shibue,Yasemin Kaygusuz,Ferenc Reinhardt,Elinor Ng Eaton,Robert A. Weinberg +7 more
TL;DR: It is shown that normal gland-reconstituting mammary stem cells residing in the basal layer of the mammary epithelium and breast TICs originating in the luminal layer exploit the paralogous EMT-TFs Slug and Snail, respectively, which induce distinct EMT programs.