E
Elisabeth A. Boström
Researcher at Karolinska Institutet
Publications - 42
Citations - 4268
Elisabeth A. Boström is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Saliva & Periodontitis. The author has an hindex of 16, co-authored 41 publications receiving 3424 citations. Previous affiliations of Elisabeth A. Boström include Sahlgrenska University Hospital & Brigham and Women's Hospital.
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Journal ArticleDOI
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Pontus Boström,Jun Wu,Mark P. Jedrychowski,Anisha Korde,Li Ye,James C. Lo,Kyle A. Rasbach,Elisabeth A. Boström,Jang Hyun Choi,Jonathan Z. Long,Shingo Kajimura,Maria Cristina Zingaretti,Birgitte F. Vind,Hua Tu,Saverio Cinti,Kurt Højlund,Steven P. Gygi,Bruce M. Spiegelman +17 more
TL;DR: This article showed that PGC1α expression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is cleaved and secreted as a newly identified hormone, irisin.
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Aberrant Macrophages Mediate Defective Kidney Repair That Triggers Nephritis in Lupus-Susceptible Mice
Yasunori Iwata,Elisabeth A. Boström,Julia Menke,Whitney Rabacal,Laurence Morel,Takashi Wada,Vicki Rubin Kelley +6 more
TL;DR: I/R induces CSF-1 in injured TECs that expands aberrant Mø (M1 phenotype), mediating defective renal repair and nonresolving inflammation, and thereby hastens the onset of lupus nephritis.
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Interleukin 34: a new modulator of human and experimental inflammatory bowel disease.
Stephanie Zwicker,Gisele Lago Martinez,Madeleen Bosma,Marco Gerling,Reuben Clark,Mirjam Majster,Jan Söderman,Sven Almer,Elisabeth A. Boström +8 more
TL;DR: Different expression patterns of IL34 and CSF1 are found in ileum and colon, suggesting IL-34 as a new modulator of inflammation in IBD.
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The Newly Discovered Cytokine IL-34 Is Expressed in Gingival Fibroblasts, Shows Enhanced Expression by Pro-Inflammatory Cytokines, and Stimulates Osteoclast Differentiation
TL;DR: IL-34 expression in human gingival fibroblasts is shown for the first time, stimulated by TNF-α and IL-1β, key mediators of periodontal inflammation and can be substituted for M-CSF in RANKL-induced osteoclastogenesis.
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FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice
Madeleen Bosma,Marco Gerling,Jenny Pasto,Anastasia Georgiadi,Evan L. Graham,Olga Shilkova,Yasunori Iwata,Sven Almer,Jan Söderman,Rune Toftgård,Fredrik Wermeling,Elisabeth A. Boström,Pontus Boström +12 more
TL;DR: Treatment with FNDC4 results in a state of dampened macrophage activity, while enhancing their survival, and is characterized as a factor with direct therapeutic potential in inflammatory bowel disease and possibly other inflammatory diseases.