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Anisha Korde
Researcher at Northeastern University
Publications - 10
Citations - 4373
Anisha Korde is an academic researcher from Northeastern University. The author has contributed to research in topics: Cannabinoid receptor & Endocannabinoid system. The author has an hindex of 6, co-authored 10 publications receiving 3548 citations. Previous affiliations of Anisha Korde include University of Southern California & Harvard University.
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Journal ArticleDOI
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Pontus Boström,Jun Wu,Mark P. Jedrychowski,Anisha Korde,Li Ye,James C. Lo,Kyle A. Rasbach,Elisabeth A. Boström,Jang Hyun Choi,Jonathan Z. Long,Shingo Kajimura,Maria Cristina Zingaretti,Birgitte F. Vind,Hua Tu,Saverio Cinti,Kurt Højlund,Steven P. Gygi,Bruce M. Spiegelman +17 more
TL;DR: This article showed that PGC1α expression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is cleaved and secreted as a newly identified hormone, irisin.
Journal ArticleDOI
Crystal Structure of the Human Cannabinoid Receptor CB2.
Tian Hua,Kiran Vemuri,Mengchen Pu,Lu Qu,Lu Qu,Gye Won Han,Yiran Wu,Suwen Zhao,Wenqing Shui,Shanshan Li,Anisha Korde,Robert B. Laprairie,Edward L. Stahl,Jo-Hao Ho,Nikolai Zvonok,Han Zhou,Irina Kufareva,Beili Wu,Qiang Zhao,Michael A. Hanson,Laura M. Bohn,Alexandros Makriyannis,Raymond C. Stevens,Raymond C. Stevens,Zhi-Jie Liu,Zhi-Jie Liu +25 more
TL;DR: The structure of the CB1-AM6538 complex reveals key features of the receptor and critical interactions for antagonist binding and provides insight into the binding mode of naturally occurring CB1 ligands, such as THC, and synthetic cannabinoids.
Journal ArticleDOI
Crystal structures of agonist-bound human cannabinoid receptor CB1
Tian Hua,Kiran Vemuri,Spyros P. Nikas,Robert B. Laprairie,Yiran Wu,Lu Qu,Lu Qu,Mengchen Pu,Anisha Korde,Shan Jiang,Jo-Hao Ho,Gye Won Han,Kang Ding,Kang Ding,Xuanxuan Li,Haiguang Liu,Michael A. Hanson,Suwen Zhao,Laura M. Bohn,Alexandros Makriyannis,Raymond C. Stevens,Raymond C. Stevens,Zhi-Jie Liu,Zhi-Jie Liu +23 more
TL;DR: The structures reveal important insights into the activation mechanism of CB1 and provide a molecular basis for predicting the binding modes of Δ9-THC, and endogenous and synthetic cannabinoids and should inspire the design of chemically diverse ligands with distinct pharmacological properties.
Journal ArticleDOI
A review of multifunctional nanoemulsion systems to overcome oral and CNS drug delivery barriers.
TL;DR: Multifunctional lipid nanosystems that integrate enhancement in permeability, tissue and cell targeting, imaging, and therapeutic functions are especially promising and can serve as a safe and effective delivery vehicle across oral and CNS barriers.
Journal ArticleDOI
Gαs signalling of the CB1 receptor and the influence of receptor number.
David B. Finlay,Erin E. Cawston,Natasha L. Grimsey,Morag R. Hunter,Anisha Korde,V. Kiran Vemuri,Alexandros Makriyannis,Michelle Glass +7 more
TL;DR: The effects of receptor number and different ligands on CB1 receptor signalling are examined and the determinants of this signalling switch identified to date are examined.