E
Elisabeth M. Wood
Researcher at University of Pennsylvania
Publications - 37
Citations - 3934
Elisabeth M. Wood is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Frontotemporal lobar degeneration & Frontotemporal dementia. The author has an hindex of 23, co-authored 36 publications receiving 3437 citations. Previous affiliations of Elisabeth M. Wood include National Institutes of Health.
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Journal ArticleDOI
Stages of pTDP‐43 pathology in amyotrophic lateral sclerosis
Johannes Brettschneider,Kelly Del Tredici,Jon B. Toledo,John L. Robinson,David J. Irwin,Murray Grossman,EunRan Suh,Vivianna M. Van Deerlin,Elisabeth M. Wood,Young Min Baek,Linda K. Kwong,Edward B. Lee,Lauren Elman,Leo McCluskey,Lubin Fang,Simone Feldengut,Albert C. Ludolph,Virginia M.-Y. Lee,Heiko Braak,John Q. Trojanowski +19 more
TL;DR: To see whether the distribution patterns of phosphorylated 43kDa TAR DNA‐binding protein (pTDP‐43) intraneuronal inclusions in amyotrophic lateral sclerosis (ALS) permit recognition of neuropathological stages, a chiral model is constructed.
Journal ArticleDOI
TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis
Vivianna M. Van Deerlin,James B. Leverenz,James B. Leverenz,Lynn M. Bekris,Thomas D. Bird,Thomas D. Bird,Wuxing Yuan,Lauren Elman,Dana Clay,Elisabeth M. Wood,Alice Chen-Plotkin,Maria Martinez-Lage,Ellen J. Steinbart,Leo McCluskey,Murray Grossman,Manuela Neumann,I-Lin Wu,Wei-Shiung Yang,Robert G. Kalb,Douglas Galasko,Thomas J. Montine,John Q. Trojanowski,Virginia M.-Y. Lee,Gerard D. Schellenberg,Gerard D. Schellenberg,Chang En Yu,Chang En Yu +26 more
TL;DR: The finding of pathogenic mutations in TARDBP implicates TDP-43 as an active mediator of neurodegeneration in TDP -43 proteinopathies, a class of disorder that includes ALS and FTLD-U.
Journal ArticleDOI
Comparison of family histories in FTLD subtypes and related tauopathies
Jill Goldman,Jennifer M. Farmer,Elisabeth M. Wood,Julene K. Johnson,Adam L. Boxer,John Neuhaus,Catherine Lomen-Hoerth,Kirk C. Wilhelmsen,Virginia M. Y. Lee,Murray Grossman,Bruce L. Miller +10 more
TL;DR: Pedigrees from 269 patients with frontotemporal lobar degeneration (FTLD), including FTD, FTD with ALS, progressive nonfluent aphasia, semantic dementia, corticobasal degeneration, and progressive supranuclear palsy were analyzed to determine the degree of heritability of these disorders.
Journal ArticleDOI
CSF biomarkers in frontotemporal lobar degeneration with known pathology
H. Bian,J. C. van Swieten,Susan Leight,Lauren Massimo,Elisabeth M. Wood,Mark S. Forman,Peachie Moore,I. de Koning,Christopher M. Clark,Sonia M. Rosso,John Q. Trojanowski,Virginia M.-Y. Lee,Murray Grossman +12 more
TL;DR: The ratio of CSF tau/Aβ42 is a sensitive and specific biomarker at discriminating frontotemporal lobar degeneration from Alzheimer disease in patients with known pathology.
Journal ArticleDOI
Phenotypic variability associated with progranulin haploinsufficiency in patients with the common 1477C→T (Arg493X) mutation: an international initiative
Rosa Rademakers,Matt Baker,Jennifer Gass,Jennifer Adamson,Edward D. Huey,Parastoo Momeni,Salvatore Spina,Salvatore Spina,Giovanni Coppola,Anna Karydas,Heather Stewart,Nancy Johnson,Ging-Yuek Robin Hsiung,Brendan J. Kelley,Karen M. Kuntz,Ellen J. Steinbart,Elisabeth M. Wood,Chang En Yu,Keith A. Josephs,Eric J. Sorenson,Kyle B. Womack,Sandra Weintraub,Stuart Pickering-Brown,Peter R. Schofield,William S. Brooks,Vivianna M. Van Deerlin,Julie S. Snowden,Christopher M. Clark,Andrew Kertesz,Kevin B. Boylan,Bernardino Ghetti,David Neary,Gerard D. Schellenberg,Thomas G. Beach,M.-Marsel Mesulam,David M. A. Mann,Jordan Grafman,Ian R. A. Mackenzie,Howard Feldman,Thomas D. Bird,R. C. Petersen,David S. Knopman,Bradley F. Boeve,Daniel H. Geschwind,Bruce L. Miller,Zbigniew K. Wszolek,Carol F. Lippa,Eileen H. Bigio,Dennis W. Dickson,Neill R. Graff-Radford,Mike Hutton +50 more
TL;DR: Clinical heterogeneity is associated with GRN haploinsufficiency, and genetic variability on the wild-type GRN allele might have a role in the age-related disease penetrance of GRN mutations.