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Elisabetta Grillo
Researcher at University of Brescia
Publications - 38
Citations - 474
Elisabetta Grillo is an academic researcher from University of Brescia. The author has contributed to research in topics: Angiogenesis & Medicine. The author has an hindex of 10, co-authored 31 publications receiving 251 citations. Previous affiliations of Elisabetta Grillo include Katholieke Universiteit Leuven.
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Journal ArticleDOI
Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells.
Oliver A. Stone,Oliver A. Stone,Mohamed A. El-Brolosy,Kerstin Wilhelm,Xiaojing Liu,Ana M Romão,Elisabetta Grillo,Jason Kuan Han Lai,Jason Kuan Han Lai,Stefan Günther,Sylvia Jeratsch,Carsten Kuenne,I-Ching Lee,Thomas Braun,Massimo M. Santoro,Jason W. Locasale,Michael Potente,Didier Y.R. Stainier +17 more
TL;DR: The glycolytic enzyme pyruvate kinase M2 (PKM2) regulates methionine metabolism and DNA methylation in endothelial cells and links metabolic dysfunction with autoimmune activation in ECs.
Journal ArticleDOI
Cyclic Adenosine Monophosphate-Response Element–Binding Protein Mediates the Proangiogenic or Proinflammatory Activity of Gremlin
Michela Corsini,Emanuela Moroni,Cosetta Ravelli,Germán Andrés,Elisabetta Grillo,Imran Ali,Derek P. Brazil,Marco Presta,Stefania Mitola +8 more
TL;DR: The results underline the tight cross-talk between angiogenesis and inflammation and demonstrate a crucial role of CREB activation in the modulation of the VEGFR2-mediated proinflammatory/proangiogenic response of ECs to gremlin.
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Monomeric gremlin is a novel vascular endothelial growth factor receptor-2 antagonist.
Elisabetta Grillo,Cosetta Ravelli,Michela Corsini,Kurt Ballmer-Hofer,Luca Zammataro,Pasqua Oreste,Giorgio Zoppetti,Chiara Tobia,Roberto Ronca,Marco Presta,Stefania Mitola +10 more
TL;DR: The data show that gremlin exists in multiple forms endowed with specific bioactivities and provide new insights into the molecular bases of gremlin dimerization and propose gremlin monomer as a new inhibitor of VEGFR2 signalling during tumor growth.
Journal ArticleDOI
FGF Trapping Inhibits Multiple Myeloma Growth through c-Myc Degradation–Induced Mitochondrial Oxidative Stress
Roberto Ronca,Gaia C. Ghedini,Federica Maccarinelli,Antonio Sacco,Silvia L. Locatelli,Eleonora Foglio,Sara Taranto,Elisabetta Grillo,Sara Matarazzo,Riccardo Castelli,Giuseppe Paganini,Vanessa Desantis,Nadia Cattane,Annamaria Cattaneo,Marco Mor,Carmelo Carlo-Stella,Angelo Belotti,Aldo M. Roccaro,Marco Presta,Arianna Giacomini +19 more
TL;DR: The mechanism by which the FGF/FGFR system plays a nonredundant role in multiple myeloma cell survival and disease progression is dissected, and it is demonstrated that FGF targeting may represent a therapeutic approach for patients with multipleMyeloma with poor prognosis and advanced disease stage.
Journal ArticleDOI
Role of VEGFs in metabolic disorders.
M. di Somma,Maria Vliora,Maria Vliora,Elisabetta Grillo,Begoña Castro,Eleni Dakou,Wandert Schaafsma,Jef Vanparijs,Michela Corsini,Cosetta Ravelli,E. Sakellariou,Stefania Mitola +11 more
TL;DR: The role of vasculature network and VEGF in the adipose tissue maintenance and supplementation is discussed and angiogenesis is a key process implicated in regulation of tissues homeostasis.