E
Eliska Davidova
Researcher at Academy of Sciences of the Czech Republic
Publications - 5
Citations - 271
Eliska Davidova is an academic researcher from Academy of Sciences of the Czech Republic. The author has contributed to research in topics: Cancer cell & Downregulation and upregulation. The author has an hindex of 4, co-authored 5 publications receiving 159 citations. Previous affiliations of Eliska Davidova include Charles University in Prague.
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Journal ArticleDOI
Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.
Martina Bajzikova,Martina Bajzikova,Jaromira Kovarova,Ana R Coelho,Ana R Coelho,Stepana Boukalova,Sehyun Oh,Katerina Rohlenova,David Svec,Sona Hubackova,Berwini Endaya,Kristyna Judasova,Ayenachew Bezawork-Geleta,Katarina Kluckova,Laurent Chatre,Laurent Chatre,Renata Zobalova,Anna Novakova,Katerina Vanova,Zuzana Ezrova,Zuzana Ezrova,Ghassan J. Maghzal,Ghassan J. Maghzal,Silvia Magalhaes Novais,Silvia Magalhaes Novais,Marie Olšinová,Linda Krobova,Yong Jin An,Eliska Davidova,Eliska Davidova,Zuzana Nahacka,Margarita Sobol,Teresa Cunha-Oliveira,Cristian Sandoval-Acuña,Hynek Strnad,Tongchuan Zhang,Thanh Huynh,Teresa L. Serafim,Pavel Hozák,Vilma A. Sardão,Werner J.H. Koopman,Miria Ricchetti,Miria Ricchetti,Paulo J. Oliveira,Frantisek Kolar,Mikael Kubista,Jaroslav Truksa,Katerina Dvorakova-Hortova,Katerina Dvorakova-Hortova,Karel Pacak,Robert Gürlich,Roland Stocker,Roland Stocker,Yaoqi Zhou,Michael V. Berridge,Sunghyouk Park,Lan-Feng Dong,Jakub Rohlena,Jiri Neuzil,Jiri Neuzil +59 more
TL;DR: It is shown that pyrimidine biosynthesis dependent on respiration-linked dihydroorotate dehydrogenase (DHODH) is required to overcome cell-cycle arrest, while mitochondrial ATP generation is dispensable for tumorigenesis, pointing to inhibitors of DHODH as potential anti-cancer agents.
Journal ArticleDOI
Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2.
Sona Hubackova,Eliska Davidova,Katerina Rohlenova,Katerina Rohlenova,Jan Stursa,Lukas Werner,Ladislav Andera,Lan-Feng Dong,Mikkel G. Terp,Zdenek Hodny,Henrik J. Ditzel,Henrik J. Ditzel,Jakub Rohlena,Jiri Neuzil,Jiri Neuzil +14 more
TL;DR: The anticancer agent mitochondria-targeted tamoxifen (MitoTam), unlike conventional anticancer agents, kills cancer cells without inducing senescence in vitro and in vivo, and also selectively eliminates both malignant and non-cancerous senescent cells.
Journal ArticleDOI
Replication and ribosomal stress induced by targeting pyrimidine synthesis and cellular checkpoints suppress p53-deficient tumors.
Sona Hubackova,Eliska Davidova,Eliska Davidova,Stepana Boukalova,Jaromira Kovarova,Martina Bajzikova,Ana R Coelho,Mikkel G. Terp,Henrik J. Ditzel,Henrik J. Ditzel,Jakub Rohlena,Jiri Neuzil,Jiri Neuzil +12 more
TL;DR: It is demonstrated that inhibition of dihydroorotate dehydrogenase (DHODH), a key enzyme of the de novo pyrimidine synthesis pathway, effectively decreases proliferation of cancer cells via induction of replication and ribosomal stress in a p53- and checkpoint kinase 1 (Chk1)-dependent manner.
Journal ArticleDOI
Mitochondria-driven elimination of cancer and senescent cells
Sona Hubackova,Silvia Magalhaes Novais,Eliska Davidova,Jiri Neuzil,Jiri Neuzil,Jakub Rohlena +5 more
TL;DR: In this article, mitochondria and OXPHOS were used for the selective removal of cancer and senescent cells, where the interplay between ATP transporters and mitochondria appeared important for the maintenance of mitochondrial morphology and viability.
Journal ArticleDOI
Selective elimination of senescent cells by mitochondrial targeting is regulated via ANT2
Sona Hubackova,Eliska Davidova,Katerina Rohlenova,Jan Stursa,Lukas Werner,Ladislav Andera,Lanfeng Dong,Mikkel G. Terp,Zdenek Hodny,Henrik J. Ditzel,Jakub Rohlena,Jiri Neuzil +11 more
TL;DR: The ability of MitoTam to eliminate senescent cells results in new strategy for treatment of age-related pathologies and senescence-associated inflammation or tumorigenesis.