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Yong Jin An
Researcher at Seoul National University
Publications - 21
Citations - 504
Yong Jin An is an academic researcher from Seoul National University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 11, co-authored 14 publications receiving 356 citations. Previous affiliations of Yong Jin An include Inha University.
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Journal ArticleDOI
Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.
Martina Bajzikova,Martina Bajzikova,Jaromira Kovarova,Ana R Coelho,Ana R Coelho,Stepana Boukalova,Sehyun Oh,Katerina Rohlenova,David Svec,Sona Hubackova,Berwini Endaya,Kristyna Judasova,Ayenachew Bezawork-Geleta,Katarina Kluckova,Laurent Chatre,Laurent Chatre,Renata Zobalova,Anna Novakova,Katerina Vanova,Zuzana Ezrova,Zuzana Ezrova,Ghassan J. Maghzal,Ghassan J. Maghzal,Silvia Magalhaes Novais,Silvia Magalhaes Novais,Marie Olšinová,Linda Krobova,Yong Jin An,Eliska Davidova,Eliska Davidova,Zuzana Nahacka,Margarita Sobol,Teresa Cunha-Oliveira,Cristian Sandoval-Acuña,Hynek Strnad,Tongchuan Zhang,Thanh Huynh,Teresa L. Serafim,Pavel Hozák,Vilma A. Sardão,Werner J.H. Koopman,Miria Ricchetti,Miria Ricchetti,Paulo J. Oliveira,Frantisek Kolar,Mikael Kubista,Jaroslav Truksa,Katerina Dvorakova-Hortova,Katerina Dvorakova-Hortova,Karel Pacak,Robert Gürlich,Roland Stocker,Roland Stocker,Yaoqi Zhou,Michael V. Berridge,Sunghyouk Park,Lan-Feng Dong,Jakub Rohlena,Jiri Neuzil,Jiri Neuzil +59 more
TL;DR: It is shown that pyrimidine biosynthesis dependent on respiration-linked dihydroorotate dehydrogenase (DHODH) is required to overcome cell-cycle arrest, while mitochondrial ATP generation is dispensable for tumorigenesis, pointing to inhibitors of DHODH as potential anti-cancer agents.
Journal ArticleDOI
Real-time monitoring of cancer cell metabolism and effects of an anticancer agent using 2D in-cell NMR spectroscopy
TL;DR: The proposed real-time metabolomic monitoring of live cancer cells using (13) C6 -glucose and heteronuclear two-dimensional (2D) NMR revealed previously unknown functional targets of galloflavin, which were further confirmed at the protein levels.
Journal ArticleDOI
BMP4 Upregulation Is Associated with Acquired Drug Resistance and Fatty Acid Metabolism in EGFR-Mutant Non-Small-Cell Lung Cancer Cells.
Duc-Hiep Bach,Thi-Thu-Trang Luu,Donghwa Kim,Yong Jin An,Sunghyouk Park,Hyen Joo Park,Sang Kook Lee +6 more
TL;DR: A novel role of BMP4-mediated tumorigenesis in the progression of acquired drug resistance in EGFR-mutant NSCLC cells is suggested.
Journal ArticleDOI
An NMR metabolomics approach for the diagnosis of leptomeningeal carcinomatosis in lung adenocarcinoma cancer patients
Yong Jin An,Hye Rim Cho,Tae Min Kim,Bhumsuk Keam,Jin Wook Kim,He Wen,Chul-Kee Park,Se-Hoon Lee,Seock-Ah Im,Jeong Eun Kim,Seung Hong Choi,Seung Hong Choi,Sunghyouk Park +12 more
TL;DR: It is proposed that the metabolomic approach might augment current diagnostic modalities for LC, the accurate diagnosis of which remains a challenge.
Journal ArticleDOI
Metabotyping of the C. elegans sir-2.1 Mutant Using in Vivo Labeling and 13C-Heteronuclear Multidimensional NMR Metabolomics
TL;DR: An efficient workflow for in vivo(13)C-labeling of C. elegans and (13)heteronuclear NMR metabolomics is applied to characterizing the metabolic phenotypes of the sir-2.1 mutant, suggesting the relationship between the metabotypes, especially the branched chain amino acids, and the roles of sir-1.1 in the worm lifespan.