M
Marie Olšinová
Researcher at Charles University in Prague
Publications - 12
Citations - 255
Marie Olšinová is an academic researcher from Charles University in Prague. The author has contributed to research in topics: Membrane & Transmembrane protein. The author has an hindex of 5, co-authored 11 publications receiving 160 citations. Previous affiliations of Marie Olšinová include Academy of Sciences of the Czech Republic.
Papers
More filters
Journal ArticleDOI
Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.
Martina Bajzikova,Martina Bajzikova,Jaromira Kovarova,Ana R Coelho,Ana R Coelho,Stepana Boukalova,Sehyun Oh,Katerina Rohlenova,David Svec,Sona Hubackova,Berwini Endaya,Kristyna Judasova,Ayenachew Bezawork-Geleta,Katarina Kluckova,Laurent Chatre,Laurent Chatre,Renata Zobalova,Anna Novakova,Katerina Vanova,Zuzana Ezrova,Zuzana Ezrova,Ghassan J. Maghzal,Ghassan J. Maghzal,Silvia Magalhaes Novais,Silvia Magalhaes Novais,Marie Olšinová,Linda Krobova,Yong Jin An,Eliska Davidova,Eliska Davidova,Zuzana Nahacka,Margarita Sobol,Teresa Cunha-Oliveira,Cristian Sandoval-Acuña,Hynek Strnad,Tongchuan Zhang,Thanh Huynh,Teresa L. Serafim,Pavel Hozák,Vilma A. Sardão,Werner J.H. Koopman,Miria Ricchetti,Miria Ricchetti,Paulo J. Oliveira,Frantisek Kolar,Mikael Kubista,Jaroslav Truksa,Katerina Dvorakova-Hortova,Katerina Dvorakova-Hortova,Karel Pacak,Robert Gürlich,Roland Stocker,Roland Stocker,Yaoqi Zhou,Michael V. Berridge,Sunghyouk Park,Lan-Feng Dong,Jakub Rohlena,Jiri Neuzil,Jiri Neuzil +59 more
TL;DR: It is shown that pyrimidine biosynthesis dependent on respiration-linked dihydroorotate dehydrogenase (DHODH) is required to overcome cell-cycle arrest, while mitochondrial ATP generation is dispensable for tumorigenesis, pointing to inhibitors of DHODH as potential anti-cancer agents.
Journal ArticleDOI
Peripheral and Integral Membrane Binding of Peptides Characterized by Time-Dependent Fluorescence Shifts: Focus on Antimicrobial Peptide LAH4
Radek Macháň,Piotr Jurkiewicz,Agnieszka Olżyńska,Marie Olšinová,Marek Cebecauer,Arnaud Marquette,Burkhard Bechinger,Martin Hof +7 more
TL;DR: These experiments suggest that the time-dependent fluorescence shift (TDFS) of Laurdan can help when distinguishing between peripheral and integral membrane binding and can be a useful, novel tool for studying the impact of transmembrane peptides (TMP) on membrane organization under near-physiological conditions.
Journal ArticleDOI
Di- and tri-oxalkyl derivatives of a boron dipyrromethene (BODIPY) rotor dye in lipid bilayers.
Marie Olšinová,Piotr Jurkiewicz,Michal Poznik,Radek Šachl,Tereza Prausová,Martin Hof,Václav Kozmík,Filip Teplý,Jiří Svoboda,Marek Cebecauer +9 more
TL;DR: The limits of BODIPY-based molecular rotors as environmental sensors in cellular membranes with complex lipid composition are demonstrated and the results strongly indicate that fluorescence properties of such probes are influenced not only by lipid packing but also by the orientation of the probe in membranes.
Journal ArticleDOI
Expansion microscopy facilitates quantitative super-resolution studies of cytoskeletal structures in kinetoplastid parasites
Peter Gorilak,Peter Gorilak,Martina Pružincová,Hana Váchová,Marie Olšinová,Marketa Schmidt Cernohorska,Vladimir Varga +6 more
TL;DR: Expansion microscopy (ExM) has become a powerful super-resolution method in cell biology as mentioned in this paper, which does not require any instrumentation or reagents beyond those present in a standard microscopy facility.
Journal ArticleDOI
Roughness of Transmembrane Helices Reduces Lipid Membrane Dynamics.
Marie Olšinová,Piotr Jurkiewicz,Iryna Kishko,Jan Sýkora,Jan Sabo,Martin Hof,Lukasz Cwiklik,Marek Cebecauer +7 more
TL;DR: Using synthetic peptides, it is demonstrated that transmembrane helices interfere with the mobility of membrane components by trapping lipid acyl chains on their rough surfaces, suggesting that roughness is a general property of helical trans Membrane segments that affects local membrane dynamics and organization.