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Emira Ayroldi
Researcher at University of Perugia
Publications - 76
Citations - 4335
Emira Ayroldi is an academic researcher from University of Perugia. The author has contributed to research in topics: Apoptosis & T cell. The author has an hindex of 29, co-authored 73 publications receiving 4064 citations. Previous affiliations of Emira Ayroldi include University of Messina.
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Journal ArticleDOI
A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death.
F. D'Adamio,Ornella Zollo,R. Moraca,Emira Ayroldi,Stefano Bruscoli,Andrea Bartoli,Lorenza Cannarile,Graziella Migliorati,Carlo Riccardi +8 more
TL;DR: GILZ expression selectively protects T cells from apoptosis induced by treatment with anti-CD3 monoclonal antibody but not by treatment of other apoptotic stimuli, and correlates with inhibition of Fas and Fas ligand expression.
Journal ArticleDOI
GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations
Simona Ronchetti,Ornella Zollo,Stefano Bruscoli,Massimiliano Agostini,Rodolfo Bianchini,Giuseppe Nocentini,Emira Ayroldi,Carlo Riccardi +7 more
TL;DR: The results show that the proliferation response of CD8+ and CD4+ peripheral T cell subpopulations was potentiated when a GITR costimulus was added to an anti‐CD3 stimulus, suggesting a novel function for G ITR as costimulatory molecule of T cell subsets.
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Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy.
Ursula Grohmann,Claudia Volpi,Francesca Fallarino,Silvia Bozza,Roberta Bianchi,Carmine Vacca,Ciriana Orabona,Maria Laura Belladonna,Emira Ayroldi,Giuseppe Nocentini,Louis Boon,Francesco Bistoni,Maria C. Fioretti,Luigina Romani,Carlo Riccardi,Paolo Puccetti +15 more
TL;DR: It is shown that reverse signaling through GITRL after engagement by soluble GITR initiates the immunoregulatory pathway of tryptophan catabolism in mouse plasmacytoid dendritic cells, by means of noncanonical NF-κB–dependent induction of indoleamine 2,3-dioxygenase (IDO).
Journal ArticleDOI
Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor κB
Emira Ayroldi,Graziella Migliorati,Stefano Bruscoli,Cristina Marchetti,Ornella Zollo,Lorenza Cannarile,F. D'Adamio,Carlo Riccardi +7 more
TL;DR: A new molecular mechanism involved in the dexamethasone-induced regulation of NF-kappaB activity and T-cell activation is identified and is identified as GILZ-mediated modulation of TCR-induced responses.
Journal ArticleDOI
Glucocorticoid-induced leucine zipper (GILZ): a new important mediator of glucocorticoid action
Emira Ayroldi,Carlo Riccardi +1 more
TL;DR: The finding that GILZ silencing abrogates the antiproliferative activity of dexamethasone and reduces GC inhibition of cytokine‐induced COX‐2 expression clearly gained GILz a distinguished reputation within the critical mediators of GC effects.