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Emma Raitoharju
Researcher at University of Tampere
Publications - 64
Citations - 4001
Emma Raitoharju is an academic researcher from University of Tampere. The author has contributed to research in topics: Population & Gene. The author has an hindex of 25, co-authored 57 publications receiving 2886 citations.
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Journal ArticleDOI
Integrative approaches for large-scale transcriptome-wide association studies.
Alexander Gusev,Alexander Gusev,Arthur Ko,Huwenbo Shi,Gaurav Bhatia,Gaurav Bhatia,Wonil Chung,Brenda W.J.H. Penninx,Rick Jansen,Eco J. C. de Geus,Dorret I. Boomsma,Fred A. Wright,Patrick F. Sullivan,Patrick F. Sullivan,Elina Nikkola,Marcus Alvarez,Mete Civelek,Aldons J. Lusis,Terho Lehtimäki,Emma Raitoharju,Mika Kähönen,Ilkka Seppälä,Olli T. Raitakari,Olli T. Raitakari,Johanna Kuusisto,Markku Laakso,Alkes L. Price,Alkes L. Price,Päivi Pajukanta,Bogdan Pasaniuc +29 more
TL;DR: A powerful strategy that integrates gene expression measurements with summary association statistics from large-scale genome-wide association studies (GWAS) to identify genes whose cis-regulated expression is associated with complex traits is introduced.
Journal ArticleDOI
miR-21, miR-210, miR-34a, and miR-146a/b are up-regulated in human atherosclerotic plaques in the Tampere Vascular Study
Emma Raitoharju,Leo-Pekka Lyytikäinen,Mari Levula,Niku Oksala,Ari Mennander,Matti Tarkka,Norman Klopp,Thomas Illig,Mika Kähönen,Pekka J. Karhunen,Reijo Laaksonen,Terho Lehtimäki +11 more
TL;DR: The microRNA expression profile differs significantly between atherosclerotic plaques and control arteries, and the most up-regulated miRNAs are involved in processes known to be connected to atherosclerosis.
Journal ArticleDOI
Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors
Ari Ahola-Olli,Peter Würtz,Aki S. Havulinna,Kristiina Aalto,Niina Pitkänen,Terho Lehtimäki,Mika Kähönen,Leo-Pekka Lyytikäinen,Emma Raitoharju,Ilkka Seppälä,Antti-Pekka Sarin,Samuli Ripatti,A. Palotie,Markus Perola,Jorma S. A. Viikari,Jorma S. A. Viikari,Sirpa Jalkanen,Mikael Maksimow,Veikko Salomaa,Marko Salmi,Johannes Kettunen,Olli T. Raitakari,Olli T. Raitakari,Olli T. Raitakari +23 more
TL;DR: In this paper, the causal roles of cytokine signaling and upstream inflammation in immune-related and other chronic diseases were clarified using a genome-wide association study (GWAS) of up to 8,293 Finns.
Journal ArticleDOI
The Biomarker GlycA Is Associated with Chronic Inflammation and Predicts Long-Term Risk of Severe Infection
Scott C. Ritchie,Peter Würtz,Artika P. Nath,Gad Abraham,Aki S. Havulinna,Aki S. Havulinna,Liam G. Fearnley,Antti-Pekka Sarin,Antti J. Kangas,Pasi Soininen,Pasi Soininen,Kristiina Aalto,Ilkka Seppälä,Emma Raitoharju,Marko Salmi,Marko Salmi,Mikael Maksimow,Mikael Maksimow,Satu Männistö,Mika Kähönen,Markus Juonala,Samuli Ripatti,Terho Lehtimäki,Sirpa Jalkanen,Markus Perola,Markus Perola,Olli T. Raitakari,Olli T. Raitakari,Veikko Salomaa,Mika Ala-Korpela,Johannes Kettunen,Johannes Kettunen,Johannes Kettunen,Michael Inouye +33 more
TL;DR: It is demonstrated that GlycA is a biomarker for chronic inflammation, neutrophil activity, and risk of future severe infection, and the utility of leveraging multi-layered omics data and health records to elucidate the molecular and cellular processes associated with biomarkers.
Journal ArticleDOI
Evidence HDAC9 Genetic Variant Associated With Ischemic Stroke Increases Risk via Promoting Carotid Atherosclerosis
Hugh S. Markus,Kari-Matti Mäkelä,Steve Bevan,Emma Raitoharju,Niku Oksala,Joshua C. Bis,Christopher J. O'Donnell,Atticus H. Hainsworth,Terho Lehtimäki +8 more
TL;DR: The results are consistent with the 7p21.1 association acting via promoting atherosclerosis, and consistent with alterations in HDAC9 expression mediating this increased risk, and further studies are required to confirm this link.