A
Arthur Ko
Researcher at University of California, Los Angeles
Publications - 41
Citations - 5425
Arthur Ko is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Genome-wide association study & Adipose tissue. The author has an hindex of 17, co-authored 41 publications receiving 4224 citations. Previous affiliations of Arthur Ko include University of North Carolina at Chapel Hill & University of Washington.
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Journal ArticleDOI
Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations
Brian J. O'Roak,Laura Vives,Santhosh Girirajan,Emre Karakoc,Niklas Krumm,Bradley P. Coe,Roie Levy,Arthur Ko,Choli Lee,Joshua D. Smith,Emily H. Turner,Ian B. Stanaway,Benjamin Vernot,Maika Malig,Carl Baker,Beau Reilly,Joshua M. Akey,Elhanan Borenstein,Elhanan Borenstein,Mark J. Rieder,Deborah A. Nickerson,Raphael Bernier,Jay Shendure,Evan E. Eichler,Evan E. Eichler +24 more
TL;DR: It is shown that de novo point mutations are overwhelmingly paternal in origin (4:1 bias) and positively correlated with paternal age, consistent with the modest increased risk for children of older fathers to develop ASD.
Journal ArticleDOI
Integrative approaches for large-scale transcriptome-wide association studies.
Alexander Gusev,Alexander Gusev,Arthur Ko,Huwenbo Shi,Gaurav Bhatia,Gaurav Bhatia,Wonil Chung,Brenda W.J.H. Penninx,Rick Jansen,Eco J. C. de Geus,Dorret I. Boomsma,Fred A. Wright,Patrick F. Sullivan,Patrick F. Sullivan,Elina Nikkola,Marcus Alvarez,Mete Civelek,Aldons J. Lusis,Terho Lehtimäki,Emma Raitoharju,Mika Kähönen,Ilkka Seppälä,Olli T. Raitakari,Olli T. Raitakari,Johanna Kuusisto,Markku Laakso,Alkes L. Price,Alkes L. Price,Päivi Pajukanta,Bogdan Pasaniuc +29 more
TL;DR: A powerful strategy that integrates gene expression measurements with summary association statistics from large-scale genome-wide association studies (GWAS) to identify genes whose cis-regulated expression is associated with complex traits is introduced.
Journal ArticleDOI
Copy number variation detection and genotyping from exome sequence data
Niklas Krumm,Peter H. Sudmant,Arthur Ko,Brian J. O'Roak,Maika Malig,Bradley P. Coe,Aaron R. Quinlan,Deborah A. Nickerson,Evan E. Eichler +8 more
TL;DR: A novel method using singular value decomposition (SVD) normalization to discover rare genic copy number variants (CNVs) as well as genotype copy number polymorphic (CNP) loci with high sensitivity and specificity from exome sequencing data is developed.
Journal ArticleDOI
Estimating the human mutation rate using autozygosity in a founder population
Catarina D. Campbell,Jessica X. Chong,Maika Malig,Arthur Ko,Beth L. Dumont,Lide Han,Laura Vives,Brian J. O'Roak,Peter H. Sudmant,Jay Shendure,Mark Abney,Carole Ober,Evan E. Eichler,Evan E. Eichler +13 more
TL;DR: A non-uniform distribution of heterozygous SNVs (both newly identified and known) in the autozygous segments is observed, which is suggestive of mutational hotspots or sites of long-range gene conversion.
Journal ArticleDOI
Accurate estimation of cell composition in bulk expression through robust integration of single-cell information.
Brandon Jew,Marcus Alvarez,Elior Rahmani,Zong Miao,Arthur Ko,Kristina M. Garske,Jae Hoon Sul,Kirsi H. Pietiläinen,Kirsi H. Pietiläinen,Päivi Pajukanta,Eran Halperin +10 more
TL;DR: Bisque is a highly efficient tool to measure cellular heterogeneity in bulk expression through robust integration of single-cell information, suitable for the analysis of large genomic datasets that are becoming ubiquitous.