K
Kari-Matti Mäkelä
Researcher at University of Tampere
Publications - 21
Citations - 1281
Kari-Matti Mäkelä is an academic researcher from University of Tampere. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 14, co-authored 21 publications receiving 1078 citations.
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Journal ArticleDOI
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia
Virginie J. M. Verhoeven,Pirro G. Hysi,Robert Wojciechowski,Robert Wojciechowski,Qiao Fan,Jeremy A. Guggenheim,René Höhn,Stuart MacGregor,Alex W. Hewitt,Alex W. Hewitt,Abhishek Nag,Ching-Yu Cheng,Ching-Yu Cheng,Ekaterina Yonova-Doing,Xin Zhou,M. Kamran Ikram,M. Kamran Ikram,Gabriëlle H.S. Buitendijk,George McMahon,John P. Kemp,Beate St Pourcain,Claire L. Simpson,Kari-Matti Mäkelä,Terho Lehtimäki,Mika Kähönen,Andrew D. Paterson,S. Mohsen Hosseini,Hoi Suen Wong,Liang Xu,Jost B. Jonas,Olavi Pärssinen,Juho Wedenoja,Shea Ping Yip,Daniel W.H. Ho,Daniel W.H. Ho,Chi Pui Pang,Li Jia Chen,Kathryn P. Burdon,Jamie E Craig,Barbara E.K. Klein,Ronald Klein,Toomas Haller,Andres Metspalu,Chiea Chuen Khor,Chiea Chuen Khor,E-Shyong Tai,Tin Aung,Tin Aung,Eranga N. Vithana,Wan Ting Tay,Veluchamy A. Barathi,Veluchamy A. Barathi,Myopia (Cream),Peng Chen,Ruoying Li,Jiemin Liao,Yingfeng Zheng,Rick Twee-Hee Ong,Angela Döring,Complications Trial,Complications (Dcct),David M. Evans,Nicholas J. Timpson,Annemieke J.M.H. Verkerk,Thomas Meitinger,Olli T. Raitakari,Felicia Hawthorne,Tim D. Spector,Lennart C. Karssen,Mario Pirastu,Federico Murgia,Wei Ang,Aniket Mishra,Grant W. Montgomery,Craig E. Pennell,Phillippa M. Cumberland,Ioana Cotlarciuc,Paul Mitchell,Jie Jin Wang,Jie Jin Wang,Maria Schache,Sarayut Janmahasatian,Robert P. Igo,Jonathan H. Lass,Emily Y. Chew,Sudha K. Iyengar,Theo G. M. F. Gorgels,Igor Rudan,Caroline Hayward,Alan F. Wright,Ozren Polasek,Zoran Vatavuk,James F. Wilson,Brian W Fleck,Tanja Zeller,Alireza Mirshahi,Christian P. Müller,André G. Uitterlinden,Fernando Rivadeneira,Johannes R. Vingerling,Albert Hofman,Ben A. Oostra,Najaf Amin,Arthur A.B. Bergen,Yik Ying Teo,Jugnoo S Rahi,Jugnoo S Rahi,Jugnoo S Rahi,Veronique Vitart,Cathy Williams,Paul N. Baird,Tien Yin Wong,Tien Yin Wong,Konrad Oexle,Norbert Pfeiffer,David A. Mackey,David A. Mackey,Terri L. Young,Cornelia M. van Duijn,Seang-Mei Saw,Seang-Mei Saw,Seang-Mei Saw,Joan E. Bailey-Wilson,Joan E. Bailey-Wilson,Dwight Stambolian,Caroline C W Klaver,Caroline C W Klaver,Christopher J Hammond,Christopher J Hammond +128 more
TL;DR: The CREAM consortium conducted genome-wide meta-analyses, which identified 16 new loci for refractive error in individuals of European ancestry and 8 were shared with Asians, and identified 8 additional associated loci.
Journal ArticleDOI
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error
Ching-Yu Cheng,Ching-Yu Cheng,Maria Schache,M. Kamran Ikram,M. Kamran Ikram,M. Kamran Ikram,Terri L. Young,Terri L. Young,Jeremy A. Guggenheim,Veronique Vitart,Stuart MacGregor,Virginie J. M. Verhoeven,Veluchamy A. Barathi,Veluchamy A. Barathi,Jiemin Liao,Jiemin Liao,Pirro G. Hysi,Joan E. Bailey-Wilson,Beate St Pourcain,John P. Kemp,George McMahon,Nicholas J. Timpson,David M. Evans,Grant W. Montgomery,Aniket Mishra,Ya Xing Wang,Jie Jin Wang,Jie Jin Wang,Elena Rochtchina,Ozren Polasek,Alan F. Wright,Najaf Amin,Elisabeth M. van Leeuwen,James F. Wilson,Craig E. Pennell,Cornelia M. van Duijn,Paulus T. V. M. de Jong,Paulus T. V. M. de Jong,Paulus T. V. M. de Jong,Johannes R. Vingerling,Xin Zhou,Peng Chen,Ruoying Li,Wan Ting Tay,Yingfeng Zheng,Merwyn Chew,Kathryn P. Burdon,Jamie E Craig,Sudha K. Iyengar,Robert P. Igo,Jonathan H. Lass,Emily Y. Chew,Toomas Haller,Evelin Mihailov,Andres Metspalu,Juho Wedenoja,Claire L. Simpson,Robert Wojciechowski,Robert Wojciechowski,René Hoehn,Alireza Mirshahi,Tanja Zeller,Norbert Pfeiffer,Karl J. Lackner,Thomas Bettecken,Thomas Meitinger,Konrad Oexle,Mario Pirastu,Laura Portas,Abhishek Nag,Katie M Williams,Ekaterina Yonova-Doing,Ronald Klein,Barbara E.K. Klein,S. Mohsen Hosseini,Andrew D. Paterson,Kari-Matti Mäkelä,Terho Lehtimäki,Mika Kähönen,Olli T. Raitakari,Nagahisa Yoshimura,Fumihiko Matsuda,Li Jia Chen,Chi Pui Pang,Shea Ping Yip,Maurice Yap,Akira Meguro,Nobuhisa Mizuki,Hidetoshi Inoko,Paul J. Foster,Jing Hua Zhao,Eranga N. Vithana,E-Shyong Tai,Qiao Fan,Liang Xu,Harry Campbell,Brian W Fleck,Igor Rudan,Tin Aung,Tin Aung,Albert Hofman,André G. Uitterlinden,Goran Benčić,Chiea Chuen Khor,Chiea Chuen Khor,Hannah Forward,Olavi Pärssinen,Paul Mitchell,Fernando Rivadeneira,Alex W. Hewitt,Alex W. Hewitt,Cathy Williams,Ben A. Oostra,Yik Ying Teo,Christopher J Hammond,Dwight Stambolian,David A. Mackey,David A. Mackey,Caroline C W Klaver,Tien Yin Wong,Tien Yin Wong,Seang-Mei Saw,Seang-Mei Saw,Paul N. Baird +123 more
TL;DR: This paper conducted a meta-analysis of genome-wide association studies for ocular axial length (AL) and confirmed one previously reported AL locus (ZC3H11B).
Journal ArticleDOI
Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error
Qiao Fan,Qiao Fan,Virginie J. M. Verhoeven,Robert Wojciechowski,Robert Wojciechowski,Veluchamy A. Barathi,Pirro G. Hysi,Jeremy A. Guggenheim,René Höhn,René Höhn,Veronique Vitart,Anthony P Khawaja,Kenji Yamashiro,S. Mohsen Hosseini,Terho Lehtimäki,Yi Lu,Toomas Haller,Jing Xie,Cécile Delcourt,Mario Pirastu,Juho Wedenoja,Puya Gharahkhani,Cristina Venturini,Cristina Venturini,Masahiro Miyake,Alex W. Hewitt,Alex W. Hewitt,Xiaobo Guo,Johanna Mazur,Jenifer E. Huffman,Katie M Williams,Ozren Polasek,Harry Campbell,Igor Rudan,Zoran Vatavuk,James F. Wilson,Peter K. Joshi,George McMahon,Beate St Pourcain,David M. Evans,David M. Evans,Claire L. Simpson,Tae Hwi Schwantes-An,Robert P. Igo,Alireza Mirshahi,Audrey Cougnard-Gregoire,Céline Bellenguez,Maria Blettner,Olli T. Raitakari,Mika Kähönen,Ilkka Seppälä,Tanja Zeller,Thomas Meitinger,Janina S. Ried,Christian Gieger,Laura Portas,Elisabeth M. van Leeuwen,Najaf Amin,André G. Uitterlinden,Fernando Rivadeneira,Albert Hofman,Johannes R. Vingerling,Ya Xing Wang,Xu Wang,Eileen Tai-Hui Boh,M. Kamran Ikram,M. Kamran Ikram,Charumathi Sabanayagam,Charumathi Sabanayagam,Preeti Gupta,Vincent Tan,Lei Zhou,Candice E H Ho,Wan’E. Lim,Roger W. Beuerman,Rosalynn Grace Siantar,Rosalynn Grace Siantar,E. Shyong Tai,Eranga N. Vithana,Evelin Mihailov,Chiea Chuen Khor,Chiea Chuen Khor,Chiea Chuen Khor,Caroline Hayward,Robert Luben,Paul J. Foster,Barbara E.K. Klein,Ronald Klein,Hoi Suen Wong,Paul Mitchell,Andres Metspalu,Tin Aung,Tin Aung,Terri L. Young,Mingguang He,Olavi Pärssinen,Cornelia M. van Duijn,Jie Jin Wang,Cathy Williams,Jost B. Jonas,Jost B. Jonas,Yik Ying Teo,David A. Mackey,David A. Mackey,Konrad Oexle,Nagahisa Yoshimura,Andrew D. Paterson,Norbert Pfeiffer,Tien Yin Wong,Paul N. Baird,Dwight Stambolian,Joan E. Bailey Wilson,Ching-Yu Cheng,Ching-Yu Cheng,Christopher J Hammond,Caroline C W Klaver,Seang-Mei Saw,Jugnoo S Rahi,Jugnoo S Rahi,Jean-François Korobelnik,Jean-François Korobelnik,John P. Kemp,Nicholas J. Timpson,George Davey Smith,Jamie E Craig,Kathryn P. Burdon,Rhys Fogarty,Sudha K. Iyengar,Emily Y. Chew,Sarayut Janmahasatian,Nicholas G. Martin,Stuart MacGregor,Liang Xu,Maria Schache,Vinay Nangia,Songhomitra Panda-Jonas,Alan F. Wright,Jeremy Fondran,Jonathan H. Lass,Sheng Feng,Jing Hua Zhao,Kay-Tee Khaw,Nicholas J. Wareham,Taina Rantanen,Jaakko Kaprio,Jaakko Kaprio,Chi Pui Pang,Li Jia Chen,Pancy O. S. Tam,Vishal Jhanji,Alvin L. Young,Angela Döring,Leslie J. Raffel,Mary Frances Cotch,Xiaohui Li,Shea Ping Yip,Maurice Yap,Ginevra Biino,Simona Vaccargiu,Maurizio Fossarello,Brian W Fleck,Seyhan Yazar,Seyhan Yazar,Jan Willem L Tideman,Milly S. Tedja,Margaret M. DeAngelis,Margaux A. Morrison,Lindsay A. Farrer,Xiangtian Zhou,Wei Chen,Nobuhisa Mizuki,Akira Meguro,Kari-Matti Mäkelä +172 more
TL;DR: Six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error are identified and represent an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.
Journal ArticleDOI
Evidence HDAC9 Genetic Variant Associated With Ischemic Stroke Increases Risk via Promoting Carotid Atherosclerosis
Hugh S. Markus,Kari-Matti Mäkelä,Steve Bevan,Emma Raitoharju,Niku Oksala,Joshua C. Bis,Christopher J. O'Donnell,Atticus H. Hainsworth,Terho Lehtimäki +8 more
TL;DR: The results are consistent with the 7p21.1 association acting via promoting atherosclerosis, and consistent with alterations in HDAC9 expression mediating this increased risk, and further studies are required to confirm this link.
Journal ArticleDOI
High Intestinal Cholesterol Absorption Is Associated With Cardiovascular Disease and Risk Alleles in ABCG8 and ABO: Evidence From the LURIC and YFS Cohorts and From a Meta-Analysis
Guenther Silbernagel,M. John Chapman,Bernd Genser,Bernd Genser,Marcus E. Kleber,Marcus E. Kleber,Marcus E. Kleber,Guenter Fauler,Hubert Scharnagl,Tanja B. Grammer,Bernhard O. Boehm,Kari-Matti Mäkelä,Mika Kähönen,Rafael Carmena,Ernst Rietzschel,Ernst Rietzschel,Eric Bruckert,John E. Deanfield,Tatu A. Miettinen,Olli T. Raitakari,Olli T. Raitakari,Terho Lehtimäki,Winfried März,Winfried März,Winfried März +24 more
TL;DR: Harm caused by elevated cholesterol absorption rather than by plant sterols may therefore mediate the relationships of ABCG8 and ABO variants with CVD.