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Emyr Lloyd-Evans
Researcher at Cardiff University
Publications - 63
Citations - 3632
Emyr Lloyd-Evans is an academic researcher from Cardiff University. The author has contributed to research in topics: Lysosomal storage disease & Biology. The author has an hindex of 22, co-authored 48 publications receiving 3159 citations. Previous affiliations of Emyr Lloyd-Evans include National Institutes of Health & University of Oxford.
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Journal ArticleDOI
Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium
Emyr Lloyd-Evans,Anthony J. Morgan,Xingxuan He,David Smith,Elena Elliot-Smith,Daniel J. Sillence,Grant C. Churchill,Edward H. Schuchman,Antony Galione,Frances M. Platt +9 more
TL;DR: It is found that NPC1-mutant cells have a large reduction in the acidic compartment calcium store compared to wild-type cells, which represents a new target for therapeutic intervention, as elevation of cytosolic calcium with curcumin normalized NPC1 disease cellular phenotypes and prolonged survival of the NPC1 mouse.
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Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease
TL;DR: The role of the Ca2+-mobilizing messenger NAADP (nicotinic acid adenine dinucleotide phosphate) as a major regulator of Ca2+, and the recent discovery of an endolysosomal channel family, the TPCs (two-pore channels), as its principal intracellular targets are discussed.
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Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification
Ju-Hyun Lee,Mary Kate McBrayer,Devin M. Wolfe,Luke J. Haslett,Asok Kumar,Yutaka Sato,Pearl P.Y. Lie,Panaiyur S. Mohan,Panaiyur S. Mohan,Erin E. Coffey,Uday B. Kompella,Claire H. Mitchell,Emyr Lloyd-Evans,Ralph A. Nixon,Ralph A. Nixon +14 more
TL;DR: The results indicate that vATPase deficiency in PS1 loss-of-function states causes lysosomal/autophagy deficits and contributes to abnormal cellular Ca(2+) homeostasis, thus linking two AD-related pathogenic processes through a common molecular mechanism.
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Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca2+ Signaling and Endolysosomal Trafficking
Margarida Ruas,Katja Rietdorf,Abdelilah Arredouani,Lianne C. Davis,Emyr Lloyd-Evans,Heidi Koegel,Timothy M. Funnell,Anthony J. Morgan,John A. Ward,Keiko Watanabe,Xiaotong Cheng,Grant C. Churchill,Michael X. Zhu,Frances M. Platt,Gary M. Wessel,John Parrington,Antony Galione +16 more
TL;DR: This study shows that immunopurified endogenous TPC complexes possess the hallmark properties ascribed to NAADP receptors, including nanomolar ligand affinity, and proposes that NAadP regulates endolysosomal Ca2+ storage and release via TPCs and coordinates endoplasmic reticulum Ca2+.
Journal ArticleDOI
Accumulation of glycosphingolipids in niemann-pick C disease disrupts endosomal transport
Danielle te Vruchte,Emyr Lloyd-Evans,Robert Jan Veldman,Robert Jan Veldman,David C. A. Neville,Raymond A. Dwek,Frances M. Platt,Wim J. van Blitterswijk,Daniel J. Sillence +8 more
TL;DR: It is suggested that accumulating GSL is part of a mislocalized membrane microdomain and is responsible for the deficit in endocytic trafficking found in Niemann-Pick type C disease.