P
Panaiyur S. Mohan
Researcher at Nathan Kline Institute for Psychiatric Research
Publications - 30
Citations - 4485
Panaiyur S. Mohan is an academic researcher from Nathan Kline Institute for Psychiatric Research. The author has contributed to research in topics: Autophagy & Lysosome. The author has an hindex of 20, co-authored 30 publications receiving 3914 citations. Previous affiliations of Panaiyur S. Mohan include New York University.
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Journal ArticleDOI
Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
Ju-Hyun Lee,Ju-Hyun Lee,W. Haung Yu,W. Haung Yu,Asok Kumar,Asok Kumar,Sooyeon Lee,Sooyeon Lee,Panaiyur S. Mohan,Panaiyur S. Mohan,Corrinne M. Peterhoff,Devin M. Wolfe,Marta Martinez-Vicente,Ashish C. Massey,Guy Sovak,Yasuo Uchiyama,David Westaway,Ana Maria Cuervo,Ralph A. Nixon,Ralph A. Nixon +19 more
TL;DR: It is shown that macroautophagy requires the Alzheimer's disease-related protein presenilin-1 (PS1) for v-ATPase targeting to lysosomes, lysOSome acidification, and proteolysis during autophagy, which represents a basis for pathogenic protein accumulations and neuronal cell death in AD.
Journal ArticleDOI
Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease
W. Haung Yu,Ana Maria Cuervo,Asok Kumar,Corrinne M. Peterhoff,Stephen D. Schmidt,Ju-Hyun Lee,Ju-Hyun Lee,Panaiyur S. Mohan,Panaiyur S. Mohan,Marc Mercken,Mark R. Farmery,Lars O. Tjernberg,Ying Jiang,Ying Jiang,Karen Duff,Karen Duff,Yasuo Uchiyama,Jan Näslund,Paul M. Mathews,Paul M. Mathews,Anne M. Cataldo,Ralph A. Nixon,Ralph A. Nixon +22 more
TL;DR: It is shown that neuronal macroautophagy is induced early in Alzheimer's disease (AD) and before β-amyloid (Aβ) deposits extracellularly in the presenilin (PS) 1/Aβ precursor protein (APP) mouse model of β- amyloidosis.
Journal ArticleDOI
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits.
Dun-Sheng Yang,Dun-Sheng Yang,Philip Stavrides,Panaiyur S. Mohan,Panaiyur S. Mohan,Susmita Kaushik,Asok Kumar,Asok Kumar,Masuo Ohno,Masuo Ohno,Stephen D. Schmidt,Daniel W. Wesson,Daniel W. Wesson,Urmi Bandyopadhyay,Ying Jiang,Ying Jiang,Monika Pawlik,Corrinne M. Peterhoff,Austin J. Yang,Donald A. Wilson,Donald A. Wilson,Peter St George-Hyslop,David Westaway,Paul M. Mathews,Paul M. Mathews,Efrat Levy,Efrat Levy,Ana Maria Cuervo,Ralph A. Nixon,Ralph A. Nixon +29 more
TL;DR: The findings support the pathogenic significance of autophagic-lysosomal dysfunction in Alzheimer's disease and indicate the potential value of restoring normal autophagy as an innovative therapeutic strategy for Alzheimer’s disease.
Journal ArticleDOI
Caspase-Mediated Fragmentation of Calpain Inhibitor Protein Calpastatin during Apoptosis
Kevin K.W. Wang,Rand Posmantur,Ravi Nadimpalli,Rathna Nath,Panaiyur S. Mohan,Ralph A. Nixon,Robert V. Talanian,Martha Keegan,Linda Herzog,Hamish Allen +9 more
TL;DR: It is reported that the endogenous calpain inhibitor calpastatin is fragmented by caspase(s) to various extents during early apoptosis in two cell types and proposed that the proteolysis of calpastatins might have yet unidentified effects on the cross-talk between the two protease systems.
Journal ArticleDOI
Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification
Ju-Hyun Lee,Mary Kate McBrayer,Devin M. Wolfe,Luke J. Haslett,Asok Kumar,Yutaka Sato,Pearl P.Y. Lie,Panaiyur S. Mohan,Panaiyur S. Mohan,Erin E. Coffey,Uday B. Kompella,Claire H. Mitchell,Emyr Lloyd-Evans,Ralph A. Nixon,Ralph A. Nixon +14 more
TL;DR: The results indicate that vATPase deficiency in PS1 loss-of-function states causes lysosomal/autophagy deficits and contributes to abnormal cellular Ca(2+) homeostasis, thus linking two AD-related pathogenic processes through a common molecular mechanism.