Mary Kate McBrayer

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: The results indicate that vATPase deficiency in PS1 loss-of-function states causes lysosomal/autophagy deficits and contributes to abnormal cellular Ca(2+) homeostasis, thus linking two AD-related pathogenic processes through a common molecular mechanism.

TL;DR: This work reports a striking rescue from mutant tau toxicity in the JNPL3 mouse model of tauopathy, and shows that pathological activation of calpains gives rise to a range of potentially toxic forms of t Tau, directly, and by activating cdk5.