E
Eric G. Neilson
Researcher at Northwestern University
Publications - 247
Citations - 31746
Eric G. Neilson is an academic researcher from Northwestern University. The author has contributed to research in topics: Antigen & Immune system. The author has an hindex of 73, co-authored 247 publications receiving 29759 citations. Previous affiliations of Eric G. Neilson include University of Kansas & University of Michigan.
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Specificity of Goodpasture autoantibodies for the recombinant noncollagenous domains of human type IV collagen.
Eric G. Neilson,Raghuram Kalluri,Mae Jane Sun,Sripad Gunwar,Theodore M. Danoff,Mariko Mariyama,Jeanne C. Myers,Stephen T. Reeders,Billy G. Hudson +8 more
TL;DR: It is unambiguously establish that GP antibodies are specifically targeted to the NC1 domain of the alpha 3(IV) chain of human type IV collagen and establish a methodology for large scale preparation of r alpha 3 (IV)NC1 domain for use in diagnostic tests and development of therapeutic procedures.
Journal ArticleDOI
TNFα induces expression of the chemoattractant cytokine RANTES in cultured mouse mesangial cells
Gunter Wolf,Stefan Aberle,Friedrich Thaiss,Peter J. Nelson,Alan M. Krensky,Eric G. Neilson,Rolf A.K. Stahl +6 more
TL;DR: The results indicate that mesangial cells produce the small cytokine RANTES, which, in concert with other chemoattractants, may play a role in the glomerular recruitment of inflammatory cells like macrophages/monocytes.
Journal Article
Cell-mediated immunity in interstitial nephritis. III. T lymphocyte-mediated fibroblast proliferation and collagen synthesis: an immune mechanism for renal fibrogenesis.
TL;DR: It is suggested that immune mechanisms and altered lymphocyte function may play an important role in the development, progression, and regulation of renal fibrogenesis in intersititial nephritis.
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Reactive oxygen species expose cryptic epitopes associated with autoimmune goodpasture syndrome.
TL;DR: It is suggested that ROS can alter the hexameric structure of type IV collagen to expose or destroy selectively immunologic epitopes embedded in basement membrane and play an important role in shaping post-translational epitope diversity or neoantigen formation in organ tissues.