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Eric R. Fearon
Researcher at University of Michigan
Publications - 183
Citations - 55140
Eric R. Fearon is an academic researcher from University of Michigan. The author has contributed to research in topics: Wnt signaling pathway & Gene. The author has an hindex of 84, co-authored 179 publications receiving 52910 citations. Previous affiliations of Eric R. Fearon include Johns Hopkins University School of Medicine & Johns Hopkins University.
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Journal ArticleDOI
A genetic model for colorectal tumorigenesis
Eric R. Fearon,Bert Vogelstein +1 more
TL;DR: A model for the genetic basis of colorectal neoplasia that includes the following salient features is presented, which may be applicable to other common epithelial neoplasms, in which tumors of varying stage are more difficult to study.
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Genetic alterations during colorectal-tumor development.
Bert Vogelstein,Eric R. Fearon,Stanley R. Hamilton,Scott E. Kern,Ann C. Preisinger,Mark Leppert,A M Smits,Johannes L. Bos +7 more
TL;DR: It is found that ras-gene mutations occurred in 58 percent of adenomas larger than 1 cm and in 47 percent of carcinomas, which are consistent with a model of colorectal tumorigenesis in which the steps required for the development of cancer often involve the mutational activation of an oncogene coupled with the loss of several genes that normally suppress tumors.
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Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas
Suzanne J. Baker,Eric R. Fearon,Janice M. Nigro,Stanley R. Hamilton,Ann C. Preisinger,J. Milburn Jessup,P vanTuinen,David H. Ledbetter,David F. Barker,Yusuke Nakamura,Ray White,Bert Vogelstein +11 more
TL;DR: The data suggest that p53 gene mutations may be involved in colorectal neoplasia, perhaps through inactivation of a tumor suppressor function of the wild-type p53 genes.
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Prevalence of ras gene mutations in human colorectal cancers
Johannes L. Bos,Matty Verlaan de Vries,Alex J. van der Eb,Eric R. Fearon,Bert Vogelstein,Stanley R. Hamilton,Jacques H. van Boom +6 more
TL;DR: A combination of DNA hybridization analyses and tissue sectioning techniques demonstrate that ras gene mutations occur in over a third of human colorectal cancers, that most of the mutations are at codon 12 of the c-Ki-ras gene and that the mutations usually precede the development of malignancy.
Journal ArticleDOI
Suppression of human colorectal carcinoma cell growth by wild-type p53.
TL;DR: It is shown that the wild-type gene can specifically suppress the growth of human colorectal carcinoma cells in vitro and that an in vivo-derived mutation resulting in a single conservative amino acid substitution in the p53 gene product abrogates this suppressive ability.