E
Erietta Stelekati
Researcher at University of Pennsylvania
Publications - 25
Citations - 4263
Erietta Stelekati is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Cytotoxic T cell & CD8. The author has an hindex of 19, co-authored 22 publications receiving 3307 citations. Previous affiliations of Erietta Stelekati include Drexel University & University of Miami.
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Journal ArticleDOI
Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer
Christina Twyman-Saint Victor,Andrew J. Rech,Amit Maity,Ramesh Rengan,Ramesh Rengan,Kristen E. Pauken,Erietta Stelekati,Joseph L. Benci,Bihui Xu,Hannah Dada,Pamela M. Odorizzi,Ramin S. Herati,Kathleen D. Mansfield,Dana Patsch,Ravi K. Amaravadi,Lynn M. Schuchter,Hemant Ishwaran,Rosemarie Mick,Daniel A. Pryma,Xiaowei Xu,Michael Feldman,Tara C. Gangadhar,Stephen M. Hahn,E. John Wherry,Robert H. Vonderheide,Andy J. Minn +25 more
TL;DR: Major tumour regressions are reported in a subset of patients with metastatic melanoma treated with an anti-CTLA4 antibody and radiation and reproduced this effect in mouse models, showing that PD-L1 on melanoma cells allows tumours to escape anti- NCTLA4-based therapy, and the combination of radiation, anti- CTLA4 and anti-PD-L 1 promotes response and immunity through distinct mechanisms.
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Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8+ T Cell Exhaustion
Bertram Bengsch,Andy L. Johnson,Makoto Kurachi,Pamela M. Odorizzi,Kristen E. Pauken,John Attanasio,Erietta Stelekati,Laura M. McLane,Michael A. Paley,Greg M. Delgoffe,E. John Wherry +10 more
TL;DR: A key metabolic control event early in exhaustion is highlighted and it is suggested that manipulating glycolytic and mitochondrial metabolism might enhance checkpoint blockade outcomes.
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TCF-1-Centered Transcriptional Network Drives an Effector Versus Exhausted CD8 T Cell-Fate Decision
Zeyu Chen,Zhicheng Ji,Shin Foong Ngiow,Sasikanth Manne,Zhangying Cai,Alexander C. Huang,John L. Johnson,Ryan P. Staupe,Bertram Bengsch,Caiyue Xu,Sixiang Yu,Makoto Kurachi,Ramin S. Herati,Laura A. Vella,Laura A. Vella,Amy E. Baxter,Jennifer E. Wu,Omar Khan,Jean Christophe Beltra,Josephine R. Giles,Erietta Stelekati,Laura M. McLane,Chi Wai Lau,Xiaolu Yang,Shelley L. Berger,Golnaz Vahedi,Hongkai Ji,E. John Wherry +27 more
TL;DR: A role for TCF-1 in early-fate-bifurcation-driving Tex precursor cells is defined and PD-1 is identified as a protector of this early TCf-1 subset.
Journal ArticleDOI
The microRNA miR-155 controls CD8 + T cell responses by regulating interferon signaling
Donald T. Gracias,Erietta Stelekati,Jennifer L. Hope,Alina C. Boesteanu,Travis A. Doering,Jillian A. Norton,Yvonne M. Mueller,Joseph A. Fraietta,E. John Wherry,Martin R Turner,Peter D. Katsikis +10 more
TL;DR: A previously unknown role for miR-155 is identified in regulating responsiveness to interferon and CD8+ T cell responses to pathogens in vivo.
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Cutting Edge: IL-4, IL-21, and IFN-γ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells.
Martin S. Naradikian,Arpita Myles,Daniel P. Beiting,Kenneth J. Roberts,Lucas Dawson,Ramin S. Herati,Bertram Bengsch,Susanne L. Linderman,Erietta Stelekati,Rosanne Spolski,E. John Wherry,Christopher A. Hunter,Scott E. Hensley,Warren J. Leonard,Michael P. Cancro +14 more
TL;DR: The findings suggest that T-bet+ B cells seen in health and disease share the common initiating features of TLR-driven activation within this circumscribed cytokine milieu.