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Erik C. B. Johnson
Researcher at Johns Hopkins University Applied Physics Laboratory
Publications - 89
Citations - 2452
Erik C. B. Johnson is an academic researcher from Johns Hopkins University Applied Physics Laboratory. The author has contributed to research in topics: Computer science & Medicine. The author has an hindex of 18, co-authored 62 publications receiving 1665 citations. Previous affiliations of Erik C. B. Johnson include Emory University & University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
Insights from atomic-resolution X-ray structures of chemically synthesized HIV-1 protease in complex with inhibitors.
Erik C. B. Johnson,Enrico Malito,Yuequan Shen,Brad L. Pentelute,Dan Rich,Jan Florián,Wei-Jen Tang,Stephen B. H. Kent +7 more
TL;DR: At atomic-resolution structures revealed additional structural details of the HIV-1 PR's interactions with its active site ligands, and putative catalytically competent reactant states for both lytic water and direct nucleophilic attack mechanisms were found.
Journal ArticleDOI
A small molecule targeting protein translation does not rescue spatial learning and memory deficits in the hAPP-J20 mouse model of Alzheimer’s disease
Erik C. B. Johnson,Jing Kang +1 more
TL;DR: This study aimed to test whether ISRIB would reverse learning and memory deficits in the J20 mouse model of human amyloid precursor protein (hAPP) overexpression, a model that simulates many aspects of Alzheimer’s disease.
Posted ContentDOI
Integrated Proteomics Reveals Brain-Based Cerebrospinal Fluid Biomarkers in Asymptomatic and Symptomatic Alzheimer’s Disease
Lenora Higginbotham,Lingyan Ping,Eric B. Dammer,Duc M. Duong,Maotian Zhou,Marla Gearing,Erik C. B. Johnson,Ihab Hajjar,James J. Lah,Allan I. Levey,Nicholas T. Seyfried +10 more
TL;DR: Overall, these brain-linked CSF biomarker panels represent a promising step toward a physiologically comprehensive tool that could meaningfully enhance the prognostic and therapeutic management of AD.
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Fulminant encephalopathy with basal ganglia hyperintensities in HIV-infected drug users.
TL;DR: A unique clinical syndrome of a fulminant encephalopathy associated with primarily basal ganglia involvement in HIV-infected drug abusers is described, a rare but serious condition that is associated with a high mortality rate.
Journal ArticleDOI
Multi-platform proteomic analysis of Alzheimer’s disease cerebrospinal fluid and plasma reveals network biomarkers associated with proteostasis and the matrisome
Eric B. Dammer,Lingyan Ping,Duc M. Duong,Erica Modeste,Nicholas T. Seyfried,James J. Lah,Allan I. Levey,Erik C. B. Johnson +7 more
TL;DR: In this article , the authors used SomaLogic SomaScan, Olink proximity extension assay, and tandem mass tag-based mass spectrometry to assess which protein markers in these two biofluids may serve as reliable biomarkers of AD pathophysiology observed from unbiased brain proteomics studies.