Erika Lorenzo-Vivas

TL;DR: It is found that microglia from germ-free mice exhibited dysregulation of dozens of genes associated with the adult phase and immune response, including MAFB, which led to disruption of homeostasis in adulthood and increased expression of interferon and inflammation pathways.

TL;DR: A high-sensitivity indexing-first chromatin immunoprecipitation approach to profile the dynamics of four chromatin modifications across 16 stages of hematopoietic differentiation and reveals that lineage commitment involves de novo establishment of 17,035 lineage-specific enhancers.

TL;DR: The spectrum of transcriptional identities of small intestinal ILCs is characterized and how I LCs differentially integrate signals from the microbial microenvironment to generate phenotypic and functional plasticity is described.

TL;DR: It is shown that monocyte differentiation occurred through de novo enhancer establishment and activation of pre‐established (poised) enhancers, and it is revealed that while Ly6C+ and Ly 6C− monocytes are homogeneous in steady state,Ly6Cint cells display heterogeneity.

TL;DR: In this article , the authors assessed the association of subclinical atherosclerosis with accelerated epigenetic age and investigated the underlying mechanisms mediating this association, concluding that systemic inflammation plays a key role in this association and reinforcing the relevance of interventions on inflammation to prevent cardiovascular disease.