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Stephanie Vargas Aguilar
Researcher at Weizmann Institute of Science
Publications - 6
Citations - 997
Stephanie Vargas Aguilar is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 4 publications receiving 696 citations. Previous affiliations of Stephanie Vargas Aguilar include Aix-Marseille University.
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Journal ArticleDOI
Microglia development follows a stepwise program to regulate brain homeostasis
Orit Matcovitch-Natan,Deborah R. Winter,Amir Giladi,Stephanie Vargas Aguilar,Amit Spinrad,Sandrine Sarrazin,Sandrine Sarrazin,Sandrine Sarrazin,Hila Ben-Yehuda,Eyal David,Fabiola Zelada González,Fabiola Zelada González,Fabiola Zelada González,Pierre Perrin,Pierre Perrin,Pierre Perrin,Hadas Keren-Shaul,Meital Gury,David Lara-Astaiso,Christoph A. Thaiss,Merav Cohen,Keren Bahar Halpern,Kuti Baruch,Aleksandra Deczkowska,Erika Lorenzo-Vivas,Shalev Itzkovitz,Eran Elinav,Michael H. Sieweke,Michal Schwartz,Ido Amit +29 more
TL;DR: It is found that microglia from germ-free mice exhibited dysregulation of dozens of genes associated with the adult phase and immune response, including MAFB, which led to disruption of homeostasis in adulthood and increased expression of interferon and inflammation pathways.
Journal ArticleDOI
SIRT1 regulates macrophage self‐renewal
Francesco Imperatore,Julien Maurizio,Stephanie Vargas Aguilar,Clara Jana-Lui Busch,Jeremy Favret,Elisabeth Kowenz-Leutz,Wilfried Cathou,Rebecca Gentek,Pierre Perrin,Achim Leutz,Carole Berruyer,Michael H. Sieweke +11 more
TL;DR: It is shown that SIRT1, an evolutionary conserved regulator of life span, positively affects macrophage self‐renewal ability in vitro and in vivo, and suggests that macrophages self‐Renewal might be a relevant parameter of ageing.
Journal ArticleDOI
ImmGen at 15
Stephanie Vargas Aguilar,Oscar M Aguilar,Rhys S. Allan,El-ad David Amir,Veronique Angeli,Maxim N. Artyomov,Natasha Asinovski,Jilian Astarita,K. Frank Austen,Geetika Bajpai,Nora A. Barrett,Alev Baysoy,Christophe Benoist,Angelique Bellemare-Pelletier,Brad Berg,Adam J Best,Natalie A. Bezman,David A. Blair,Julie M. Blander,Milena Bogunovic,Patrick J. Brennan,Michael B. Brenner,Brian D. Brown,Matthew B. Buechler,Jason D. Buenrostro,Maria Acebes Casanova,Kyunghee Choi,Andrew Chow,Aleksey Chudnovskiy,Daniela Cipoletta,Nadia Cohen,James J. Collins,Marco Colonna,Alison Cook,James C. Costello,Viviana Cremasco,Ty Crowl,Karine Crozat,Richard M. Cruse,June D'Angelo,Marc Dalod,Scott Davis,Çağatay Demiralp,Tianda Deng,Jigar V. Desai,Fiona Desland,Maxime Dhainaut,Jiarui Ding,Andrew L. Doedens,Claudia X. Dominguez,Graeme Doran,Regine J. Dress,Michael L. Dustin,Daniel F. Dwyer,Ivan Dzhagalov,Kutlu G. Elpek,Ayla Ergun,Jeff Ericson,Eunice Esomonu,Keke Fairfax,Anne L. Fletcher,Michela Frascoli,Anja Fuchs,Anastasiia Gainullina,Shani T. Gal-Oz,Michael P. Gallagher,Emmanuel L. Gautier,Roi Gazit,Sophie L. Gibbings,Matthieu Giraud,Florent Ginhoux,Ananda W. Goldrath,Dagmar Gotthardt,Daniel H.D. Gray,Melanie Greter,Ricardo Grieshaber-Bouyer,Martin Guilliams,Sara Haidermota,Randy Hardy,Daigo Hashimoto,Julie Helft,Deborah W. Hendricks,Tracy Heng,Jonathan Hill,Gordon Hyatt,Juliana Idoyaga,Claudia Jakubzick,Jessica Jarjoura,Daniel Jepson,Baosen Jia,Radu Jianu,Timothy M. Johanson,Stefan Jordan,Vladimir Jojic,Yosuke Kamimura,Veronica Kana,Joonsoo Kang,Varun N. Kapoor,Ephriam Kenigsberg,Andrew Kent,Charles C. Kim,Edy Y. Kim,Francis Kim,Joel Kim,Ki-Wook Kim,Evgeny Kiner,Jamie Knell,Daphne Koller,Larry Kozinn,Karen Krchma,Taras Kreslavsky,Mitchell Kronenberg,Wing-hong Kwan,David H. Laidlaw,Viola Lam,Lewis L. Lanier,Catherine Laplace,Caleb A. Lareau,Yonit Lavin,Kory J. Lavine,Andrew Leader,Marylene Leboeuf,Jacob S. Lee,Jisu Lee,Bo Li,Hu Li,Yuesheng Li,Michail S. Lionakis,Hervé Luche,Lydia Lynch,Assaf Magen,Barbara Maier,Deepali Malhotra,Nidhi Malhotra,Marie Malissen,Alexandra Maslova,Diane Mathis,Adelle P. McFarland,Miriam Merad,Etienne Meunier,Jennifer Miller,J. Justin Milner,Michael Mingueneau,Gundula Min-Oo,Paul A. Monach,Devapregasan Moodley,Arthur Mortha,Maelig Morvan,Sara Mostafavi,Sören Müller,Christoph Muus,Tsukasa Nabekura,Tata Nageswara Rao,Vipin Narang,Kavitha Narayan,Hadas Ner-Gaon,Quyhn Nguyen,Peter A. Nigrovic,German Novakovsky,Stephan Nutt,Kayla Omilusik,Adriana Ortiz-Lopez,Helena Paidassi,Henry Paik,Michio W. Painter,Mallory Paynich,Vincent Peng,Marc Potempa,Rachana Pradhan,Jeremy Price,Yilin Qi,Yiqing Qi,Sara Quon,Ricardo Ramirez,Deepshika Ramanan,Gwendalyn J. Randolph,Aviv Regev,Andrew Rhoads,Michelle L. Robinette,Samuel A. Rose,Derrick J. Rossi,Katie Rothamel,Ravi Sachidanandam,Priyanka Sathe,Charlotte L. Scott,Kumba Seddu,Peter See,Alexey Sergushichev,Laura A Shaw,Tal Shay,Avishai Shemesh,Susan A. Shinton,Justin Shyer,Michael H. Sieweke,Christopher Smillie,Lotte Spel,Nick Spidale,Giuseppina Stifano,Ayshwarya Subramanian,Joseph C. Sun,Katelyn Sylvia,Julie Tellier,Sebastien This,Elena Tomasello,Helena Todorov,Shannon J. Turley,Brinda Vijaykumar,Amy J. Wagers,Ei Wakamatsu,Chendi Wang,Peter L. Wang,Aleksandra Wroblewska,Jun Wu,Edward Yang,Liang Yang,Aldrin Kay Yuen Yim,Lim Sheau Yng,Hideyuki Yoshida,Bingfei Yu,Yan Zhou,Yanan Zhu,Caroline Ziemkiewicz +221 more
TL;DR: Nature Immunology’s 20th anniversary is a good opportunity to reminisce about the ImmGen collective endeavor — its goals, successes and horror stories — and the group's exploration of various modes of scientific publishing.
Journal ArticleDOI
Long-term culture-expanded alveolar macrophages restore their full epigenetic identity after transfer in vivo
Sethuraman Subramanian,Clara J L Busch,Kaaweh Molawi,Laufey Geirsdottir,Julien Maurizio,Stephanie Vargas Aguilar,Hassiba Belahbib,Gregory Gimenez,R. Yuda,Michaela Burkon,Jeremy Favret,Sara Gholamhosseinian Najjar,Bérengère de Laval,Prashanth K. Kandalla,Sandrine Sarrazin,Lena Alexopoulou,Michael H. Sieweke +16 more
TL;DR: Sieweke et al. as mentioned in this paper showed that long-term ex vivo expanded AMs (exAMs) maintained a core AM gene expression program, but showed culture adaptations related to adhesion, metabolism and proliferation.
Posted ContentDOI
Open Source ImmGen: network perspective on metabolic diversity among mononuclear phagocytes
Anastasiia Gainullina,Li-Hao Huang,Helena Todorov,Ki-Wook Kim,Lim Sheau Yng,Andrew Kent,Baosen Jia,Kumba Seddu,Karen Krchma,Jun Wu,Karine Crozat,Elena Tomasello,Vipin Narang,Regine J. Dress,Peter See,Charlotte L. Scott,Sophie L. Gibbings,Geetika Bajpai,Jigar V. Desai,Barbara Maier,Sebastien This,Peter L. Wang,Stephanie Vargas Aguilar,Lucie Poupel,Sébastien Dussaud,Tyng-An Zhou,Veronique Angeli,J. Magarian Blander,Kyunghee Choi,Marc Dalod,Ivan Dzhagalov,Emmanuel L. Gautier,Claudia Jakubzick,Kory J. Lavine,Michail S. Lionakis,Helena Paidassi,Michael H. Sieweke,Florent Ginhoux,Martin Guilliams,Christophe Benoist,Miriam Merad,Gwendalyn J. Randolph,Alexey Sergushichev,Maxim N. Artyomov +43 more
TL;DR: It is demonstrated that interference with this pathway through statins administration diminishes migratory capacity of the dendritic cells in vivo, which demonstrates the power of the approach and highlights importance of metabolic diversity among mononuclear phagocytes.