E
Erinc Hallacli
Researcher at Massachusetts Institute of Technology
Publications - 12
Citations - 349
Erinc Hallacli is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: MSL complex & Dosage compensation complex. The author has an hindex of 6, co-authored 9 publications receiving 273 citations. Previous affiliations of Erinc Hallacli include Brigham and Women's Hospital & Max Planck Society.
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Journal ArticleDOI
Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1.
Jan Kadlec,Erinc Hallacli,Michael Lipp,Herbert Holz,Juan Sanchez-Weatherby,Juan Sanchez-Weatherby,Stephen Cusack,Asifa Akhtar +7 more
TL;DR: This work proposes that Msl1 acts as a scaffold for MSL complex assembly to achieve specific targeting to the X chromosome in Drosophila and shows analogous interactions of MOF with NSL1.
Journal ArticleDOI
The MOF Chromobarrel Domain Controls Genome-wide H4K16 Acetylation and Spreading of the MSL Complex
Thomas Conrad,Florence M.G. Cavalli,Herbert Holz,Erinc Hallacli,Jop Kind,Ibrahim Avsar Ilik,Juan M. Vaquerizas,Nicholas M. Luscombe,Asifa Akhtar +8 more
TL;DR: The MOF chromobarrel domain directly interacts with nucleic acids and potentiates MOF's enzymatic activity after chromatin binding, making it a unique example of a chromo-like domain directly controlling acetylation activity in vivo.
Journal ArticleDOI
A Genetic Tool to Track Protein Aggregates and Control Prion Inheritance
Gregory A. Newby,Szilvia Kiriakov,Erinc Hallacli,Erinc Hallacli,Can Kayatekin,Peter Tsvetkov,Christopher P. Mancuso,J. Maeve Bonner,William R. Hesse,Sohini Chakrabortee,Anita L. Manogaran,Susan W. Liebman,Susan Lindquist,Susan Lindquist,Ahmad S. Khalil,Ahmad S. Khalil +15 more
TL;DR: This work identifies prion-curing mutants and engineer "anti-prion drives" that reverse the non-Mendelian inheritance pattern of prions and eliminate them from yeast populations using high-throughput screens enabled by the platform.
Journal ArticleDOI
Msl1-Mediated Dimerization of the Dosage Compensation Complex Is Essential for Male X-Chromosome Regulation in Drosophila
Erinc Hallacli,Michael Lipp,Plamen Georgiev,Clare Spielman,Stephen Cusack,Asifa Akhtar,Jan Kadlec +6 more
TL;DR: It is proposed that Msl1-mediated dimerization of the entire MSL complex is required for Msl2 binding, X chromosome recognition, and spreading along the X chromosome.
Journal ArticleDOI
The Parkinson’s disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability
Erinc Hallacli,Can Kayatekin,Sumaiya Nazeen,Xiou H. Wang,Zoe R. Sheinkopf,Shubhangi Sathyakumar,Souvarish Sarkar,Xin Jiang,Xianjun Dong,Roberto Di Maio,Wen Wang,Matthew T. Keeney,Daniel Felsky,Jackson Sandoe,Aazam Vahdatshoar,Namrata D. Udeshi,D. R. Mani,Steven A. Carr,Susan Lindquist,Philip L. De Jager,David P. Bartel,Chad L. Myers,J. Timothy Greenamyre,Mel B. Feany,Shamil R. Sunyaev,Chee Yeun Chung,Vikram Khurana +26 more
TL;DR: Marras et al. as mentioned in this paper showed that αS directly modulates processing bodies (P-bodies), membraneless organelles that function in mRNA turnover and storage.