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Esther Nuebel
Researcher at University of Utah
Publications - 13
Citations - 1416
Esther Nuebel is an academic researcher from University of Utah. The author has contributed to research in topics: Mitochondrion & Induced pluripotent stem cell. The author has an hindex of 7, co-authored 13 publications receiving 1198 citations. Previous affiliations of Esther Nuebel include University of Glasgow & University of California, Los Angeles.
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Journal ArticleDOI
UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells
Jin Zhang,Ivan Khvorostov,Jason S. Hong,Yavuz Oktay,Laurent Vergnes,Esther Nuebel,Paulin N. Wahjudi,Kiyoko Setoguchi,Geng Wang,Anna Do,Hea Jin Jung,J. Michael McCaffery,Irwin J. Kurland,Karen Reue,Wai-Nang Paul Lee,Carla M. Koehler,Michael A. Teitell +16 more
TL;DR: Overall, hPSCs contain active mitochondria and require UCP2 repression for full differentiation potential, and have functional respiratory complexes that are able to consume O2 at maximal capacity.
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Metabolic Regulation in Pluripotent Stem Cells during Reprogramming and Self-Renewal
TL;DR: The emerging roles for metabolism in PSC self-renewal, differentiation, and reprogramming are discussed, with metabolite levels influencing epigenetic/genetic programs.
Journal ArticleDOI
Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells
Jin Zhang,Esther Nuebel,Dona R.R. Wisidagama,Kiyoko Setoguchi,Jason S. Hong,Christine M Van Horn,Sarah S Imam,Laurent Vergnes,Cindy S. Malone,Carla M. Koehler,Michael A. Teitell +10 more
TL;DR: Protocols for analyzing energy metabolism in hPSCs and their early differentiated progenies that are generally applicable to mature cell types as well are provided and Companion methods are provided to aid researchers in developing more sophisticated experimental regimens for extended analyses of cellular bioenergetics.
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Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis.
Emilie Hangen,Olivier Feraud,Olivier Feraud,Sylvie Lachkar,Haiwei Mou,Nunzianna Doti,Gian Maria Fimia,Ngoc vy Lam,Changlian Zhu,Isabelle Godin,Isabelle Godin,Isabelle Godin,Kevin Müller,Afroditi Chatzi,Esther Nuebel,Fabiola Ciccosanti,Stephane Flamant,Stephane Flamant,Paule Bénit,Paule Bénit,Jean-Luc Perfettini,Allan Sauvat,Annelise Bennaceur-Griscelli,Karine Ser-Le Roux,Karine Ser-Le Roux,Patrick Gonin,Patrick Gonin,Kostas Tokatlidis,Pierre Rustin,Pierre Rustin,Mauro Piacentini,Menotti Ruvo,Klas Blomgren,Klas Blomgren,Guido Kroemer,Nazanine Modjtahedi +35 more
TL;DR: This work has identified an AIF-interacting protein, CHCHD4, which is the central component of a redox-sensitive mitochondrial intermembrane space import machinery that contributes to the biogenesis of respiratory chain complexes and establishes an unexpected link between the vital function of AIF and the propensity of cells to undergo apoptosis.
Journal ArticleDOI
Primary Ovarian Insufficiency and Azoospermia in Carriers of a Homozygous PSMC3IP Stop Gain Mutation
Abdulmoein E. Al-Agha,Ihab Abdulhamed Ahmed,Esther Nuebel,Mika Moriwaki,Barry Moore,Katherine A Peacock,Tim Mosbruger,Deborah W. Neklason,Lynn B. Jorde,Mark Yandell,Corrine K. Welt +10 more
TL;DR: The PSMC3IP mutation provides additional evidence that mutations in meiotic homologous recombination and DNA repair genes result in distinct female and male reproductive phenotypes, including delayed puberty and primary amenorrhea caused by POI in females but isolated azoospermia with normal pubertal development in males.