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Allan Sauvat
Researcher at Institut Gustave Roussy
Publications - 57
Citations - 1551
Allan Sauvat is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Immunogenic cell death & Cancer cell. The author has an hindex of 17, co-authored 48 publications receiving 940 citations. Previous affiliations of Allan Sauvat include Pierre-and-Marie-Curie University & Paris Descartes University.
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Journal ArticleDOI
Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis.
Emilie Hangen,Olivier Feraud,Olivier Feraud,Sylvie Lachkar,Haiwei Mou,Nunzianna Doti,Gian Maria Fimia,Ngoc vy Lam,Changlian Zhu,Isabelle Godin,Isabelle Godin,Isabelle Godin,Kevin Müller,Afroditi Chatzi,Esther Nuebel,Fabiola Ciccosanti,Stephane Flamant,Stephane Flamant,Paule Bénit,Paule Bénit,Jean-Luc Perfettini,Allan Sauvat,Annelise Bennaceur-Griscelli,Karine Ser-Le Roux,Karine Ser-Le Roux,Patrick Gonin,Patrick Gonin,Kostas Tokatlidis,Pierre Rustin,Pierre Rustin,Mauro Piacentini,Menotti Ruvo,Klas Blomgren,Klas Blomgren,Guido Kroemer,Nazanine Modjtahedi +35 more
TL;DR: This work has identified an AIF-interacting protein, CHCHD4, which is the central component of a redox-sensitive mitochondrial intermembrane space import machinery that contributes to the biogenesis of respiratory chain complexes and establishes an unexpected link between the vital function of AIF and the propensity of cells to undergo apoptosis.
Journal ArticleDOI
eIF2α phosphorylation is pathognomonic for immunogenic cell death.
Lucillia Bezu,Allan Sauvat,Juliette Humeau,Lígia C. Gomes-da-Silva,Kristina Iribarren,Sabrina Forveille,Pauline Garcia,Liwei Zhao,Peng Liu,Laurence Zitvogel,Laurence Zitvogel,Laura Senovilla,Oliver Kepp,Guido Kroemer +13 more
TL;DR: Machine-learning approaches were used to determine the physicochemical properties of drugs that induce ICD, revealing that the sole ER stress response relevant to the algorithm is eIF2α phosphorylation with its downstream consequences CALR exposure, stress granule formation and autophagy induction.
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Contribution of RIP3 and MLKL to immunogenic cell death signaling in cancer chemotherapy
Heng Yang,Yuting Ma,Guo Chen,Heng Zhou,Takahiro Yamazaki,Christophe Klein,Federico Pietrocola,Erika Vacchelli,Sylvie Souquere,Allan Sauvat,Laurence Zitvogel,Oliver Kepp,Guido Kroemer +12 more
TL;DR: It is suggested that RIP3 and MLKL can contribute to ICD signaling and tumor immunogenicity.
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Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers.
François-Xavier Danlos,Claudia Grajeda-Iglesias,Sylvère Durand,Allan Sauvat,Mathilde Roumier,Delphine Cantin,Emeline Colomba,Julien Rohmer,Fanny Pommeret,Giulia Baciarello,Christophe Willekens,Marc Vasse,Frank Griscelli,Jean-Eudes Fahrner,Jean-Eudes Fahrner,Anne-Gaëlle Goubet,Anne-Gaëlle Goubet,Agathe Dubuisson,Agathe Dubuisson,Lisa Derosa,Lisa Derosa,Nitharsshini Nirmalathasan,Delphine Bredel,Severine Mouraud,Caroline Pradon,Annabelle Stoclin,Flore Rozenberg,Jérôme Duchemin,Georges Jourdi,Syrine Ellouze,Françoise Levavasseur,Laurence Albiges,Jean-Charles Soria,Fabrice Barlesi,Fabrice Barlesi,Eric Solary,Fabrice Andre,Fabrice Andre,Frédéric Pène,Félix Ackerman,Luc Mouthon,Laurence Zitvogel,Laurence Zitvogel,Laurence Zitvogel,Aurélien Marabelle,Jean-Marie Michot,Michaela Fontenay,Guido Kroemer +47 more
TL;DR: In this paper, the authors report alterations in the plasma metabolome reflecting the clinical presentation of COVID-19 patients with mild (ambulatory) diseases, moderate disease (radiologically confirmed pneumonitis, hospitalization and oxygen therapy), and critical disease (in intensive care).
Journal ArticleDOI
The oncolytic peptide LTX-315 triggers immunogenic cell death.
Heng Zhou,Sabrina Forveille,Allan Sauvat,Takahiro Yamazaki,Laura Senovilla,Yuting Ma,Peng Liu,Huijun Yang,Lucillia Bezu,Kevin Müller,Laurence Zitvogel,Øystein Rekdal,Oliver Kepp,Guido Kroemer +13 more
TL;DR: Results support the idea that LTX-315 can induce ICD, hence explaining its capacity to mediate immune-dependent therapeutic effects.