P
Paule Bénit
Researcher at French Institute of Health and Medical Research
Publications - 93
Citations - 8567
Paule Bénit is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Respiratory chain & Mitochondrion. The author has an hindex of 40, co-authored 89 publications receiving 7653 citations. Previous affiliations of Paule Bénit include University of Paris & Necker-Enfants Malades Hospital.
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Journal ArticleDOI
The complete DNA sequence of yeast chromosome III.
Stephen G. Oliver,Q. J. M. van der Aart,M. L. Agostoni-Carbone,Michel Aigle,Lilia Alberghina,Despina Alexandraki,G. Antoine,Rashida Anwar,Juan P. G. Ballesta,Paule Bénit,Gilbert Berben,Elisabetta Bergantino,N. Biteau,P. A. Bolle,Monique Bolotin-Fukuhara,Anthony G. A. Brown,Alistair J. P. Brown,J. M. Buhler,C. Carcano,Giovanna Carignani,Håkan Cederberg,R. Chanet,Roland Contreras,Marc Crouzet,B. Daignan-Fornier,E. Defoor,M. Delgado,Jan Demolder,C. Doira,Evelyne Dubois,Bernard Dujon,A. Düsterhöft,D. Erdmann,M. Esteban,F. Fabre,Cécile Fairhead,Gérard Faye,Horst Feldmann,Walter Fiers,M. C. Francingues-Gaillard,L. Franco,Laura Frontali,H. Fukuhara,L. J. Fuller,P. Galland,Manda E. Gent,D. Gigot,Véronique Gilliquet,Glansdorff Nn,André Goffeau,M. Grenson,P. Grisanti,Leslie A. Grivell,M. de Haan,M. Haasemann,D. Hatat,Janet Hoenicka,Johannes H. Hegemann,C. J. Herbert,François Hilger,Stefan Hohmann,Cornelis P. Hollenberg,K. Huse,F. Iborra,K. J. Indje,K. Isono,C. Jacq,M. Jacquet,C. M. James,J. C. Jauniaux,Y. Jia,Alberto Jiménez,A. Kelly,U. Kleinhans,P Kreisl,G. Lanfranchi,C Lewis,C. G. vanderLinden,G Lucchini,K Lutzenkirchen,M.J. Maat,L. Mallet,G. Mannhaupet,Enzo Martegani,A. Mathieu,C. T. C. Maurer,David J. McConnell,R. A. McKee,F. Messenguy,Hans-Werner Mewes,Francis Molemans,M. A. Montague,M. Muzi Falconi,L. Navas,Carol S. Newlon,D. Noone,C. Pallier,L. Panzeri,Bruce M. Pearson,J. Perea,Peter Philippsen,A. Pierard,Rudi J. Planta,Paolo Plevani,B. Poetsch,Fritz M. Pohl,B. Purnelle,M. Ramezani Rad,S. W. Rasmussen,A. Raynal,Miguel Remacha,P. Richterich,Aki Roberts,F. Rodriguez,E. Sanz,I. Schaaff-Gerstenschlager,Bart Scherens,Bertold Schweitzer,Y. Shu,J. Skala,Piotr P. Slonimski,F. Sor,C. Soustelle,R. Spiegelberg,Lubomira Stateva,H. Y. Steensma,S. Steiner,Agnès Thierry,George Thireos,Maria Tzermia,L. A. Urrestarazu,Giorgio Valle,I. Vetter,J. C. van Vliet-Reedijk,Marleen Voet,Guido Volckaert,P. Vreken,H. Wang,John R. Warmington,D. von Wettstein,Barton Luke Wicksteed,C. Wilson,H. Wurst,G. Xu,A. Yoshikawa,Friedrich K. Zimmermann,J. G. Sgouros +146 more
TL;DR: The entire DNA sequence of chromosome III of the yeast Saccharomyces cerevisiae has been determined, which is the first complete sequence analysis of an entire chromosome from any organism.
Journal ArticleDOI
SDH mutations establish a hypermethylator phenotype in paraganglioma.
Eric Letouzé,Cosimo Martinelli,Cosimo Martinelli,Céline Loriot,Céline Loriot,Nelly Burnichon,Nelly Burnichon,N. Abermil,Chris Ottolenghi,Chris Ottolenghi,Chris Ottolenghi,Maxime Janin,Maxime Janin,Mélanie Menara,Mélanie Menara,An Thach Nguyen,An Thach Nguyen,Paule Bénit,Alexandre Buffet,Alexandre Buffet,Charles Marcaillou,Jérôme Bertherat,Laurence Amar,Pierre Rustin,Aurélien de Reyniès,Anne-Paule Gimenez-Roqueplo,Judith Favier,Judith Favier +27 more
TL;DR: Methylome analysis of a large paraganglioma cohort identified three stable clusters, associated with distinct clinical features and mutational status, and inactivating FH mutations were identified in the only hypermethylated tumor without SDHx mutations.
Journal ArticleDOI
AIF deficiency compromises oxidative phosphorylation
Nicola Vahsen,Céline Candé,Jean Briere,Paule Bénit,Nicholas Joza,Nathanael Larochette,Pier G. Mastroberardino,Marie O. Pequignot,Noelia Casares,Vladimir Lazar,Olivier Feraud,Najet Debili,Silke Wissing,Silvia Engelhardt,Frank Madeo,Mauro Piacentini,Josef M. Penninger,Hermann Schägger,Pierre Rustin,Guido Kroemer +19 more
TL;DR: It is shown that human or mouse cells lacking AIF as a result of homologous recombination or small interfering RNA exhibit high lactate production and enhanced dependency on glycolytic ATP generation, due to severe reduction of respiratory chain complex I activity.
Journal ArticleDOI
SDHA is a tumor suppressor gene causing paraganglioma
Nelly Burnichon,J. Brière,Rossella Libé,Laure Vescovo,Julie Rivière,Julie Rivière,Frédérique Tissier,Elodie Jouanno,Xavier Jeunemaitre,Xavier Jeunemaitre,Paule Bénit,Alexander Tzagoloff,Pierre Rustin,Jérôme Bertherat,Judith Favier,Judith Favier,Anne-Paule Gimenez-Roqueplo +16 more
TL;DR: In vivo and in vitro functional studies demonstrated that the SDHA mutation causes a loss of SDH enzymatic activity in tumor tissue and in the yeast model, and should be considered as a new paraganglioma/pheochromocytoma susceptibility gene.
Journal ArticleDOI
Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
Eugenia Morselli,Guillermo Mariño,Guillermo Mariño,Guillermo Mariño,Martin V. Bennetzen,Tobias Eisenberg,Evgenia Megalou,Sabrina Schroeder,Sandra Cabrera,Paule Bénit,Pierre Rustin,Alfredo Criollo,Alfredo Criollo,Alfredo Criollo,Oliver Kepp,Oliver Kepp,Oliver Kepp,Lorenzo Galluzzi,Lorenzo Galluzzi,Lorenzo Galluzzi,Shensi Shen,Shensi Shen,Shensi Shen,Shoaib Ahmad Malik,Shoaib Ahmad Malik,Shoaib Ahmad Malik,Maria Chiara Maiuri,Maria Chiara Maiuri,Maria Chiara Maiuri,Yoshiyuki Horio,Carlos López-Otín,Jens S. Andersen,Nektarios Tavernarakis,Frank Madeo,Guido Kroemer +34 more
TL;DR: The acetylase inhibitor spermidine and the sirtuin-1 activator resveratrol disrupt the antagonistic network of acetylases and deacetylases that regulate autophagy.