E
Esther van de Vosse
Researcher at Leiden University Medical Center
Publications - 77
Citations - 4644
Esther van de Vosse is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Tuberculosis & Interleukin 12. The author has an hindex of 35, co-authored 77 publications receiving 4161 citations. Previous affiliations of Esther van de Vosse include Leiden University.
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Journal ArticleDOI
Susceptibility to leprosy is associated with PARK2 and PACRG.
Marcelo Távora Mira,Marcelo Távora Mira,Alexandre Alcaïs,Nguyen Van Thuc,Milton Ozório Moraes,Celestino Di Flumeri,Vu Hong Thai,Mai Chi Phuong,Nguyen Thu Huong,Nguyen Ngoc Ba,Pham Xuan Khoa,Euzenir Nunes Sarno,Andrea Alter,Alexandre Montpetit,Maria E. Moraes,José Reinaldo da Silva Cabral de Moraes,Carole Doré,Caroline J. Gallant,Pierre Lepage,Andrei Verner,Esther van de Vosse,Thomas J. Hudson,Laurent Abel,Erwin Schurr +23 more
TL;DR: Variants in the regulatory region shared by PARK2 and PACRG act as common risk factors for leprosy by using a systematic association scan of the chromosomal interval most likely to harbour this leproSy susceptibility locus.
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Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis.
Sonia Davila,Martin L. Hibberd,Ranjeeta Hari Dass,Hazel E. E. Wong,Edhyana Sahiratmadja,Edhyana Sahiratmadja,Carine Bonnard,Bachti Alisjahbana,Jeffrey S. Szeszko,Yanina Balabanova,Francis Drobniewski,Reinout van Crevel,Esther van de Vosse,Sergey Nejentsev,Tom H. M. Ottenhoff,Mark Seielstad +15 more
TL;DR: Evidence is provided of a role for the TLR8 gene in susceptibility to pulmonary TB across different populations for the first time, and a quantitative PCR analysis indicated thatTLR8 transcript levels are significantly up-regulated in patients during the acute phase of disease.
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A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans
Yang Li,Marije Oosting,Sanne P. Smeekens,Martin Jaeger,Raul Aguirre-Gamboa,Kieu T. T. Le,Patrick Deelen,Isis Ricaño-Ponce,Teske Schoffelen,Anne F.M. Jansen,Morris A. Swertz,Sebo Withoff,Esther van de Vosse,Marcel van Deuren,Frank L. van de Veerdonk,Alexandra Zhernakova,Jos W. M. van der Meer,Ramnik J. Xavier,Lude Franke,Leo A. B. Joosten,Cisca Wijmenga,Cisca Wijmenga,Vinod Kumar,Mihai G. Netea +23 more
TL;DR: This study provides a comprehensive picture of the genetic variants that influence six different cytokines in whole blood, blood mononuclear cells, and macrophages and demonstrates a strong impact of genetic heritability on cytokine production capacity after challenge with bacterial, fungal, viral, and non-microbial stimuli.
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Genome-Wide Expression Profiling Identifies Type 1 Interferon Response Pathways in Active Tuberculosis
Tom H. M. Ottenhoff,Ranjeeta Hari Dass,Ninghan Yang,Mingzi M. Zhang,Hazel E. E. Wong,Edhyana Sahiratmadja,Chiea Chuen Khor,Bachti Alisjahbana,Reinout van Crevel,Sangkot Marzuki,Mark Seielstad,Esther van de Vosse,Martin L. Hibberd +12 more
TL;DR: The data is highly suggestive that the innate immune type-I interferon signaling cascade could be used as a quantitative tool for monitoring active TB disease, and provides evidence that components of the patient’s blood gene expression signature bear similarities to the pulmonary and macrophage response to mycobacterial infection.
Journal ArticleDOI
Human genetics of intracellular infectious diseases: molecular and cellular immunity against mycobacteria and salmonellae
TL;DR: New findings discussed in this review provide further and sometimes surprising insights into the role of type 1 cytokines, and into the unexpected heterogeneity seen in these syndromes.