P
Patrick Deelen
Researcher at University Medical Center Groningen
Publications - 82
Citations - 8977
Patrick Deelen is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Genome-wide association study & Expression quantitative trait loci. The author has an hindex of 34, co-authored 82 publications receiving 6587 citations. Previous affiliations of Patrick Deelen include Utrecht University & University Medical Center Utrecht.
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Journal ArticleDOI
Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity.
Alexandra Zhernakova,Alexander Kurilshikov,Marc Jan Bonder,Ettje F. Tigchelaar,Melanie Schirmer,Tommi Vatanen,Zlatan Mujagic,Arnau Vich Vila,Gwen Falony,Sara Vieira-Silva,Sara Vieira-Silva,Jun Wang,Jun Wang,Floris Imhann,Eelke Brandsma,Soesma A Jankipersadsing,Marie Joossens,María Carmen Cenit,Patrick Deelen,Morris A. Swertz,Rinse K. Weersma,Edith J. M. Feskens,Mihai G. Netea,Dirk Gevers,Daisy Jonkers,Lude Franke,Yurii S. Aulchenko,Curtis Huttenhower,Curtis Huttenhower,Jeroen Raes,Jeroen Raes,Jeroen Raes,Marten H. Hofker,Ramnik J. Xavier,Cisca Wijmenga,Jingyuan Fu +35 more
TL;DR: Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-based cohort shows relations between the microbiome and 126 exogenous and intrinsic host factors, including 31 intrinsic factors, 12 diseases, 19 drug groups, 4 smoking categories, and 60 dietary factors, and an important step toward a better understanding of environment-diet-microbe-host interactions.
Journal ArticleDOI
Whole-genome sequence variation, population structure and demographic history of the Dutch population
Laurent C. Francioli,Androniki Menelaou,Sara L. Pulit,Freerk van Dijk,Pier Francesco Palamara,Clara C. Elbers,Pieter B. Neerincx,Kai Ye,Kai Ye,Victor Guryev,Wigard P. Kloosterman,Patrick Deelen,Abdel Abdellaoui,Elisabeth M. van Leeuwen,Mannis van Oven,Martijn Vermaat,Mingkun Li,Jeroen F. J. Laros,Lennart C. Karssen,Alexandros Kanterakis,Najaf Amin,Jouke-Jan Hottenga,Eric-Wubbo Lameijer,Mathijs Kattenberg,Martijn Dijkstra,Heorhiy Byelas,Jessica van Setten,Barbera D. C. van Schaik,Jan Bot,Isaac J. Nijman,Ivo Renkens,Tobias Marschall,Alexander Schönhuth,Jayne Y. Hehir-Kwa,Robert E. Handsaker,Robert E. Handsaker,Paz Polak,Mashaal Sohail,Mashaal Sohail,Dana Vuzman,Fereydoun Hormozdiari,David van Enckevort,Hailiang Mei,Vyacheslav Koval,Matthijs Moed,K. Joeri van der Velde,Fernando Rivadeneira,Fernando Rivadeneira,Fernando Rivadeneira,Karol Estrada,Carolina Medina-Gomez,Aaron Isaacs,Aaron Isaacs,Steven A. McCarroll,Marian Beekman,Anton J. M. de Craen,H. Eka D. Suchiman,Albert Hofman,Ben A. Oostra,André G. Uitterlinden,Gonneke Willemsen,Mathieu Platteel,Jan H. Veldink,Leonard H. van den Berg,Steven J. Pitts,Shobha Potluri,Purnima Sundar,David R. Cox,David R. Cox,Shamil R. Sunyaev,Johan T. den Dunnen,Mark Stoneking,Peter de Knijff,Manfred Kayser,Qibin Li,Yingrui Li,Yuanping Du,Ruoyan Chen,Hongzhi Cao,Ning Li,Sujie Cao,Jun Wang,Jasper A. Bovenberg,Itsik Pe'er,P. Eline Slagboom,Cornelia M. van Duijn,Dorret I. Boomsma,Gert-Jan B. van Ommen,Paul I.W. de Bakker,Paul I.W. de Bakker,Morris A. Swertz,Cisca Wijmenga +91 more
TL;DR: The Genome of the Netherlands (GoNL) Project is described, in which the whole genomes of 250 Dutch parent-offspring families were sequenced and a haplotype map of 20.4 million single-nucleotide variants and 1.2 million insertions and deletions were constructed.
Journal ArticleDOI
The effect of host genetics on the gut microbiome
Marc Jan Bonder,Alexander Kurilshikov,Alexander Kurilshikov,Ettje F. Tigchelaar,Zlatan Mujagic,Floris Imhann,Arnau Vich Vila,Patrick Deelen,Tommi Vatanen,Tommi Vatanen,Melanie Schirmer,Melanie Schirmer,Sanne P. Smeekens,Daria V. Zhernakova,Soesma A Jankipersadsing,Martin Jaeger,Marije Oosting,María Carmen Cenit,Ad A.M. Masclee,Morris A. Swertz,Yang Li,Vinod Kumar,Leo A. B. Joosten,Hermie J. M. Harmsen,Rinse K. Weersma,Lude Franke,Marten H. Hofker,Ramnik J. Xavier,Daisy Jonkers,Mihai G. Netea,Cisca Wijmenga,Jingyuan Fu,Alexandra Zhernakova +32 more
TL;DR: The results demonstrate the importance of understanding host–microbe interactions to gain better insight into human health and demonstrate the influence of host genetics on microbial species, pathways and gene ontology categories on the basis of metagenomic sequencing in 1,514 subjects.
Posted ContentDOI
Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis
Urmo Võsa,Annique Claringbould,Harm-Jan Westra,Marc Jan Bonder,Patrick Deelen,Biao Zeng,Holger Kirsten,Ashis Saha,Roman Kreuzhuber,Silva Kasela,Natalia Pervjakova,Alvaes I,Marie-Julie Favé,Mawusse Agbessi,Mark W. Christiansen,Rick Jansen,Ilkka Seppälä,Lin Tong,Alexander Teumer,Katharina Schramm,Gibran Hemani,Joost Verlouw,Hanieh Yaghootkar,Reyhan Sonmez,Andrew A. Brown,Andrew A. Brown,Kukushkina,Anette Kalnapenkis,Sina Rüeger,Eleonora Porcu,Jaanika Kronberg-Guzman,Jarno Kettunen,Joseph E. Powell,Bernett Lee,Futao Zhang,Wibowo Arindrarto,Frank Beutner,Harm Brugge,Dmitreva J,Mahmoud Elansary,Benjamin P. Fairfax,Michel Georges,Bastiaan T. Heijmans,Mika Kähönen,Yungil Kim,Julian C. Knight,Peter Kovacs,Knut Krohn,Shuang Li,Markus Loeffler,Urko M. Marigorta,Hailiang Mei,Yukihide Momozawa,Martina Müller-Nurasyid,Matthias Nauck,Michel G. Nivard,Brenda W.J.H. Penninx,Jonathan K. Pritchard,Olli T. Raitakari,Rotzchke O,Eline Slagboom,Coen D.A. Stehouwer,Michael Stumvoll,Patrick F. Sullivan,Peter A C 't Hoen,Joachim Thiery,Anke Tönjes,van Dongen J,van Iterson M,Jan H. Veldink,Uwe Völker,C Wijmenga,Morris A. Swertz,Anand Kumar Andiappan,Grant W. Montgomery,Samuli Ripatti,Markus Perola,Z. Kutalik,Emmanouil T. Dermitzakis,Sven Bergmann,Timothy M. Frayling,van Meurs J,Holger Prokisch,Habibul Ahsan,Brandon L. Pierce,Terho Lehtimäki,D.I. Boomsma,Bruce M. Psaty,Sina A. Gharib,Philip Awadalla,Lili Milani,Willem H. Ouwehand,Kate Downes,Oliver Stegle,Alexis Battle,Jian Yang,Peter M. Visscher,Markus Scholz,Greg Gibson,Tõnu Esko,Lude Franke +100 more
TL;DR: It is observed that cis-eQTLs can be detected for 88% of the studied genes, but that they have a different genetic architecture compared to disease-associated variants, limiting the ability to use cis- eZTLs to pinpoint causal genes within susceptibility loci.
Journal ArticleDOI
Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.
Rudolf S N Fehrmann,Ritsert C. Jansen,Jan H. Veldink,Harm-Jan Westra,Danny Arends,Marc Jan Bonder,Jingyuan Fu,Patrick Deelen,Harry J.M. Groen,Asia Smolonska,Rinse K. Weersma,Rinse K. Weersma,Robert M. W. Hofstra,Wim A. Buurman,Sander S. Rensen,Marcel G. M. Wolfs,Mathieu Platteel,Alexandra Zhernakova,Clara C. Elbers,E Festen,Gosia Trynka,Marten H. Hofker,Christiaan G. J. Saris,Roel A. Ophoff,Roel A. Ophoff,Roel A. Ophoff,Leonard H. van den Berg,David A. van Heel,Cisca Wijmenga,Gerard J. te Meerman,Lude Franke,Lude Franke +31 more
TL;DR: Natural human genetic variation is relied upon to identify effects of variants on trans-gene expression (expression quantitative trait locus mapping, eQTL) in whole peripheral blood from 1,469 unrelated individuals, supporting the concept that the effects of these SNPs on expression seems to be much less multifactorial.