E
Etienne Schwob
Researcher at University of Montpellier
Publications - 53
Citations - 6409
Etienne Schwob is an academic researcher from University of Montpellier. The author has contributed to research in topics: Control of chromosome duplication & Origin recognition complex. The author has an hindex of 27, co-authored 50 publications receiving 5948 citations. Previous affiliations of Etienne Schwob include Centre national de la recherche scientifique & Yale University.
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Journal ArticleDOI
A versatile toolbox for PCR-based tagging of yeast genes: new fluorescent proteins, more markers and promoter substitution cassettes.
Carsten Janke,Maria M. Magiera,Nicole Rathfelder,Christof Taxis,Simone Reber,Hiromi Maekawa,Alexandra C. Moreno-Borchart,Georg Doenges,Etienne Schwob,Elmar Schiebel,Michael Knop,Michael Knop +11 more
TL;DR: Using the provided cassettes for N‐ and C‐terminal gene tagging or for deletion of any given gene, a set of only four primers is required, which makes this method very cost‐effective and reproducible.
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The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae
TL;DR: It is shown that DNA replication also requires activation of Cdc28 by B-type (Clb) cyclins, and proteolysis of a cyclin-specific inhibitor of CDC28 is an essential aspect of the G1 to S phase transition.
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CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae.
Etienne Schwob,Kim Nasmyth +1 more
TL;DR: The observation that CLB5 is involved in the initiation of both S phase and mitosis suggests that a single primordial B-type cyclin might have been sufficient for regulating the cell cycle of the common ancestor of many, if not all, eukaryotes.
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Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication
TL;DR: Single-molecule analyses revealed that cells with a reduced concentration of Mcm2–7 complexes display normal fork progression but have lost the potential to activate “dormant” origins that serve a backup function during DNA replication.
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The Yeast CDK Inhibitor Sic1 Prevents Genomic Instability by Promoting Replication Origin Licensing in Late G1
Armelle Lengronne,Etienne Schwob +1 more
TL;DR: Yeast lacking the CDK inhibitor Sic1 initiate DNA replication from fewer origins, have an extended S phase, and inefficiently separate sister chromatids during anaphase, indicating that Sic1 promotes origin licensing in late G(1) by preventing the untimely activation of CDKs.