E
Eugene M. Fluder
Researcher at Merck & Co.
Publications - 21
Citations - 2473
Eugene M. Fluder is an academic researcher from Merck & Co.. The author has contributed to research in topics: Chemical similarity & Latent semantic structure indexing. The author has an hindex of 13, co-authored 21 publications receiving 2170 citations.
Papers
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Journal ArticleDOI
Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
Bin Zhang,Chris Gaiteri,Liviu-Gabriel Bodea,Zhi Wang,Joshua J McElwee,Alexei A. Podtelezhnikov,Chunsheng Zhang,Tao Xie,Linh M. Tran,Radu Dobrin,Eugene M. Fluder,Bruce E. Clurman,Stacey Melquist,Manikandan Narayanan,Christine Suver,Hardik Shah,Milind Mahajan,Tammy Gillis,Jayalakshmi S. Mysore,Marcy E. MacDonald,John Lamb,David A. Bennett,Cliona Molony,David J. Stone,Vilmundur Gudnason,Amanda J. Myers,Eric E. Schadt,Harald Neumann,Jun Zhu,Valur Emilsson +29 more
TL;DR: The causal network structure is a useful predictor of response to gene perturbations and presents a framework to test models of disease mechanisms underlying LOAD.
Journal ArticleDOI
Chemical similarity using physiochemical property descriptors
Simon K. Kearsley,Susan J Sallamack,Eugene M. Fluder,Joseph D. Andose,Ralph T. Mosley,Robert P. Sheridan +5 more
TL;DR: Alternative forms of the atom pair and topological torsion descriptors that use physiochemical atom types based on binding property class, atomic log P contribution, and partial atomic charges are described.
Patent
Text influenced molecular indexing system and computer-implemented and/or computer-assisted method for same
TL;DR: In this article, an extension of the vector space model for computing chemical similarity using textual and chemical descriptors is described, which uses a chemical and/or textual description of a molecule/chemical and a decomposes a molecular/chemical descriptor matrix by a suitable technique such as singular value decomposition to create a low dimensional representation of the original descriptor space.
Journal ArticleDOI
Tautomerization of formamide, 2-pyridone, and 4-pyridone: an ab initio study
TL;DR: In this article, the effects of geometry optimization, polarization functions, correlation energy, and zero-point vibration energy are combined, and the following theoretical estimates are obtained: formimidic acid is 12 kcal/mol less stable than formamide, 2-pyridone is 0.3 kcal/m more stable than 2-hydroxypyridine and 4-hydroxyypyridine is 2.4 kcal/nm more stable.
Journal ArticleDOI
Protocols for bridging the peptide to nonpeptide gap in topological similarity searches.
TL;DR: Some simple protocols are shown that, if used with a standard topological similarity search method, are sufficient to select nonpeptide actives given a peptide probe.