F
Fabiana Kömmling Seixas
Researcher at Universidade Federal de Pelotas
Publications - 168
Citations - 3280
Fabiana Kömmling Seixas is an academic researcher from Universidade Federal de Pelotas. The author has contributed to research in topics: Leptospira & Oxidative stress. The author has an hindex of 28, co-authored 157 publications receiving 2651 citations. Previous affiliations of Fabiana Kömmling Seixas include University of Illinois at Urbana–Champaign.
Papers
More filters
Journal ArticleDOI
Chemical characterization, antioxidant and cytotoxic activities of Brazilian red propolis.
Caroline Olivieri da Silva Frozza,Charlene Silvestrin Celi Garcia,Gabriela Gambato,Marcia Denize Oliveira de Souza,Mirian Salvador,Sidnei Moura,Francine Ferreira Padilha,Fabiana Kömmling Seixas,Tiago Collares,Sibele Borsuk,Odir Antônio Dellagostin,João Antonio Pêgas Henriques,Mariana Roesch-Ely +12 more
TL;DR: The results indicate that the Brazilian red propolis is capable of inhibiting cancer cell growth and constitutes an excellent source of antioxidant and antitumor natural agent.
Journal ArticleDOI
A Genetic Porcine Model of Cancer
Lawrence B. Schook,Tiago Collares,Wenping Hu,Ying Liang,Fernanda Martins Rodrigues,Laurie A. Rund,Kyle M. Schachtschneider,Fabiana Kömmling Seixas,Kuldeep Singh,Kevin D. Wells,Eric M. Walters,Randall S. Prather,Christopher M. Counter +12 more
TL;DR: A transgenic “oncopig” line encoding Cre recombinase inducible porcine transgenes encoding KRASG12D and TP53R167H, which represent a commonly mutated oncogene and tumor suppressor in human cancers, respectively, could serve as a genetically malleable model for potentially a wide spectrum of cancers.
Journal ArticleDOI
Recombinant Mycobacterium bovis BCG expressing the LipL32 antigen of Leptospira interrogans protects hamsters from challenge.
Fabiana Kömmling Seixas,Éverton Fagonde da Silva,Daiane D. Hartwig,Gustavo C. Cerqueira,Marta G. Amaral,Michel Quevedo Fagundes,Robson Grando Dossa,Odir Antônio Dellagostin +7 more
TL;DR: In this paper, the gene coding for LipL32, a highly immunogenic antigen found in all pathogenic leptospira, was cloned into several mycobacterial vectors for expression in BCG.
Journal ArticleDOI
Characterization of virulence of Leptospira isolates in a hamster model.
Éverton Fagonde da Silva,Cleiton S. Santos,Daniel Abensur Athanazio,Núbia Seyffert,Fabiana Kömmling Seixas,Gustavo C. Cerqueira,Michel Quevedo Fagundes,Claudiomar Soares Brod,Mitermayer G. Reis,Odir Antônio Dellagostin,Albert I. Ko,Albert I. Ko +11 more
TL;DR: The potential use of Brazilian isolates as highly virulent strains in challenge experiments using hamster as an appropriate animal model for leptospirosis is demonstrated and these strains may be useful in heterologous challenge studies which aim to evaluate cross-protective responses induced by sub-unit vaccine candidates.
Journal ArticleDOI
New Organochalcogen Multitarget Drug: Synthesis and Antioxidant and Antitumoral Activities of Chalcogenozidovudine Derivatives
Diego de Souza,Douglas Oscar Ceolin Mariano,Fernanda Nedel,Eduarda Schultze,Vinicius Farias Campos,Fabiana Kömmling Seixas,Rafael S. da Silva,Taiana S. Munchen,Vinicius Ilha,Luciano Dornelles,Antonio L. Braga,João Rocha,Tiago Collares,Oscar E. D. Rodrigues +13 more
TL;DR: A prominent response was obtained for the selected chalcogenonucleosides, showing effective antioxidant and antitumoral activities.