F
Fang Fang
Researcher at Duke University
Publications - 28
Citations - 1273
Fang Fang is an academic researcher from Duke University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 13, co-authored 14 publications receiving 1042 citations. Previous affiliations of Fang Fang include University of Southern California & University of North Carolina at Chapel Hill.
Papers
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Journal ArticleDOI
Sperm methylation profiles reveal features of epigenetic inheritance and evolution in primates
Antoine Molaro,Emily Hodges,Fang Fang,Qiang Song,W. Richard McCombie,Gregory J. Hannon,Andrew D. Smith +6 more
TL;DR: The methylomes of human and chimp sperm revealed a subset of differentially methylated promoters and strikingly divergent methylation in retrotransposon subfamilies, with an evolutionary impact that is apparent in the underlying genomic sequence.
Journal ArticleDOI
A Reference Methylome Database and Analysis Pipeline to Facilitate Integrative and Comparative Epigenomics
Qiang Song,Benjamin E. Decato,Elizabeth E. Hong,Meng Zhou,Fang Fang,Jianghan Qu,Tyler Garvin,Michael D. Kessler,Jun Zhou,Andrew D. Smith +9 more
TL;DR: MethPipe, a pipeline for both low and high-level methylome analysis, and MethBase, an accompanying database of annotated methylomes from the public domain, enable researchers to extract interesting features from methylomes and compare them with those identified in public methylomes in the database.
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Genomic landscape of human allele-specific DNA methylation
TL;DR: A statistical model is presented to describe allele-specific methylation (ASM) in data from high-throughput short-read bisulfite sequencing and suggests it provides the analytical complement to cutting-edge experimental technologies for surveying ASM in specific cell types and across species.
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DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus.
Lucas Kaaij,Marc van de Wetering,Fang Fang,Benjamin E. Decato,Antoine Molaro,Harmen J.G. van de Werken,Johan H. van Es,Jurian Schuijers,Elzo de Wit,Wouter de Laat,Gregory J. Hannon,Hans Clevers,Andrew D. Smith,René F. Ketting +13 more
TL;DR: The first genome-wide, single-base-resolution view into DNA methylation dynamics during differentiation of a mammalian epithelial stem cell: the mouse small intestinal Lgr5+ stem cell is presented and it is demonstrated that Tcf4 is one of the factors contributing to formation of differentially methylated regions.
Journal ArticleDOI
FOXP1 potentiates Wnt/β-catenin signaling in diffuse large B cell lymphoma
Matthew P. Walker,Charles M. Stopford,Maria Cederlund,Fang Fang,Christopher Jahn,Alex D. Rabinowitz,Dennis Goldfarb,David M. Graham,Feng Yan,Allison M. Deal,Yuri Fedoriw,Kristy L. Richards,Ian J. Davis,Gilbert Weidinger,Blossom Damania,Michael B. Major +15 more
TL;DR: It is found that FoxP1 promoted sensitivity to Wnt pathway inhibitors, and knockdown of FOXP1 or blocking β-catenin transcriptional activity slowed xenograft tumor growth in diffuse large B cell lymphoma (DLBCL), which is a predictor of poor prognosis and resistance to therapy.