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Antoine Molaro
Researcher at Fred Hutchinson Cancer Research Center
Publications - 22
Citations - 1308
Antoine Molaro is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: DNA methylation & Histone. The author has an hindex of 9, co-authored 19 publications receiving 1104 citations. Previous affiliations of Antoine Molaro include Watson School of Biological Sciences & Howard Hughes Medical Institute.
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Journal ArticleDOI
Sperm methylation profiles reveal features of epigenetic inheritance and evolution in primates
Antoine Molaro,Emily Hodges,Fang Fang,Qiang Song,W. Richard McCombie,Gregory J. Hannon,Andrew D. Smith +6 more
TL;DR: The methylomes of human and chimp sperm revealed a subset of differentially methylated promoters and strikingly divergent methylation in retrotransposon subfamilies, with an evolutionary impact that is apparent in the underlying genomic sequence.
Journal ArticleDOI
Directional DNA Methylation Changes and Complex Intermediate States Accompany Lineage Specificity in the Adult Hematopoietic Compartment
Emily Hodges,Antoine Molaro,Antoine Molaro,Camila O. dos Santos,Camila O. dos Santos,Pramod Thekkat,Pramod Thekkat,Qiang Song,Philip J. Uren,Jin Park,Jason M. Butler,Jason M. Butler,Shahin Rafii,Shahin Rafii,W. Richard McCombie,Andrew D. Smith,Gregory J. Hannon,Gregory J. Hannon +17 more
TL;DR: In this paper, the authors characterized the methylomes of human female hematopoietic stem/progenitor cells (HSPCs) and mature cells from the myeloid and lymphoid lineages.
Journal ArticleDOI
Two waves of de novo methylation during mouse germ cell development
Antoine Molaro,Ilaria Falciatori,Emily Hodges,Alexei A. Aravin,Krista Marran,Shahin Rafii,W. Richard McCombie,Andrew D. Smith,Gregory J. Hannon +8 more
TL;DR: It is shown that most retrotransposon sequences are modified by default de novo methylation, however, potentially active retro transposon copies evade this initial wave, likely mimicking features of protein-coding genes.
Journal ArticleDOI
Genomic landscape of human allele-specific DNA methylation
TL;DR: A statistical model is presented to describe allele-specific methylation (ASM) in data from high-throughput short-read bisulfite sequencing and suggests it provides the analytical complement to cutting-edge experimental technologies for surveying ASM in specific cell types and across species.
Journal ArticleDOI
DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus.
Lucas Kaaij,Marc van de Wetering,Fang Fang,Benjamin E. Decato,Antoine Molaro,Harmen J.G. van de Werken,Johan H. van Es,Jurian Schuijers,Elzo de Wit,Wouter de Laat,Gregory J. Hannon,Hans Clevers,Andrew D. Smith,René F. Ketting +13 more
TL;DR: The first genome-wide, single-base-resolution view into DNA methylation dynamics during differentiation of a mammalian epithelial stem cell: the mouse small intestinal Lgr5+ stem cell is presented and it is demonstrated that Tcf4 is one of the factors contributing to formation of differentially methylated regions.