Fang Zheng

TL;DR: It is shown that mesenchymal-like breast cancer cells activate macrophages to a TAM-like phenotype by GM-CSF, which suggests that a positive feedback loop between GM- CSF and CCL18 is important in breast cancer metastasis.

TL;DR: The authors show that Rac1 increases glycolysis and non-oxidative pentose phosphate pathway activity leading to neoadjuvant chemotherapy (NAC) resistance, thus its inhibition sensitizes resistant breast cancer PDXs to NAC.

TL;DR: In this paper, a HIF-1α anti-sense lncRNA, HIFAL, is demonstrated to be essential for maintaining and enhancing HIF1α-mediated transactivation and glycolysis.

TL;DR: Results point toward a master regulatory role of an enhancer-activated cascade of BDNF-AS/RNH1/TRIM21/mTOR in endocrine resistance and malignant progression of breast cancer.

TL;DR: A survival analysis showed that a high expression level of ENST00000438550 was an independent indicator of disease progression in NPC patients, and may provide novel diagnostic and prognostic biomarkers for NPC and a novel understanding of the mechanism underlying NPC metastasis and potential targets for future treatment.