F
Fátima Martín-Sánchez
Researcher at Manchester Academic Health Science Centre
Publications - 18
Citations - 1683
Fátima Martín-Sánchez is an academic researcher from Manchester Academic Health Science Centre. The author has contributed to research in topics: Inflammasome & Pyroptosis. The author has an hindex of 12, co-authored 17 publications receiving 1167 citations. Previous affiliations of Fátima Martín-Sánchez include University of Manchester.
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Journal ArticleDOI
The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response.
Alberto Baroja-Mazo,Fátima Martín-Sánchez,Ana I. Gomez,Carlos Martinez,Joaquín Amores-Iniesta,Vincent Compan,Maria Barberà-Cremades,Jordi Yagüe,Estibaliz Ruiz-Ortiz,Jordi Anton,Segundo Buján,Isabelle Couillin,David Brough,Juan I. Aróstegui,Pablo Pelegrín +14 more
TL;DR: These findings support a model whereby the NLRP3 inflammasome, acting as an extracellular oligomeric complex, amplifies the inflammatory response.
Journal ArticleDOI
Inflammasome-dependent IL-1β release depends upon membrane permeabilisation.
Fátima Martín-Sánchez,Catherine Emma Diamond,Catherine Emma Diamond,Marcel Zeitler,Ana I. Gomez,Alberto Baroja-Mazo,James Bagnall,David G. Spiller,Michael R. H. White,Michael J.D. Daniels,Alessandra Mortellaro,M Peñalver,Pawel Paszek,Julia P. Steringer,Walter Nickel,David Brough,Pablo Pelegrín +16 more
TL;DR: In macrophages the release of IL-1β in response to inflammasome activation appears to be a secretory process independent of nonspecific leakage of proteins during cell death, and occurs in parallel with the death of the secreting cell.
Journal ArticleDOI
P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis
Juan J Martinez-Garcia,Helios Martínez-Banaclocha,Diego Angosto-Bazarra,Carlos de Torre-Minguela,Alberto Baroja-Mazo,Cristina Alarcón-Vila,Laura Martínez-Alarcón,Joaquín Amores-Iniesta,Fátima Martín-Sánchez,Giovanni Alessandro Ercole,Carlos Martinez,Ada Gonzalez-Lisorge,José Fernández-Pacheco,Piedad Martínez-Gil,Sahil Adriouch,Friedrich Koch-Nolte,Juan Luján,Francisco Acosta-Villegas,Pascual Parrilla,Carlos García-Palenciano,Pablo Pelegrín +20 more
TL;DR: Using a cohort of patients with intra-abdominal origin sepsis, the authors show an important role for the NLRP3 inflammasome in establishing a host response, andNLRP3 dysfunction is a common feature of sepsi mortality.
Journal ArticleDOI
Macrophage activation and polarization modify P2X7 receptor secretome influencing the inflammatory process
Carlos de Torre-Minguela,Maria Barberà-Cremades,Ana I. Gomez,Fátima Martín-Sánchez,Pablo Pelegrín +4 more
TL;DR: It is found that P2X7R stimulation in macrophages is able to release potent anti-inflammatory proteins, such as Annexin A1, independently of their polarization state suggesting for first time a potential role for P2x7R during resolution of the inflammation and not linked to the release of pro-inflammatory cytokines.
Journal ArticleDOI
Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming.
Jack Peter Green,Shi Yu,Fátima Martín-Sánchez,Pablo Pelegrín,Gloria Lopez-Castejon,Catherine B. Lawrence,David Brough +6 more
TL;DR: In insights into the dynamic nature of inflammasome oligomerization and its dependence on chloride ions are reported, revealing an additional layer of regulation and priming that can further enhance and drive inflammatory responses.