S
Segundo Buján
Researcher at Services Hospital
Publications - 3
Citations - 813
Segundo Buján is an academic researcher from Services Hospital. The author has contributed to research in topics: AIM2 & Inflammasome. The author has an hindex of 3, co-authored 3 publications receiving 678 citations.
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Journal ArticleDOI
The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response.
Alberto Baroja-Mazo,Fátima Martín-Sánchez,Ana I. Gomez,Carlos Martinez,Joaquín Amores-Iniesta,Vincent Compan,Maria Barberà-Cremades,Jordi Yagüe,Estibaliz Ruiz-Ortiz,Jordi Anton,Segundo Buján,Isabelle Couillin,David Brough,Juan I. Aróstegui,Pablo Pelegrín +14 more
TL;DR: These findings support a model whereby the NLRP3 inflammasome, acting as an extracellular oligomeric complex, amplifies the inflammatory response.
Journal ArticleDOI
Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes
Kenji Nakagawa,Eva González-Roca,Alejandro Souto,Toshinao Kawai,Hiroaki Umebayashi,Josep M. Campistol,Jeronima Cañellas,Syuji Takei,Norimoto Kobayashi,José Luis Callejas-Rubio,Norberto Ortego-Centeno,Estibaliz Ruiz-Ortiz,Fina Rius,Jordi Anton,Estibaliz Iglesias,Santiago Jimenez-Treviño,Carmen Vargas,Julian Fernandez-Martin,Inmaculada Calvo,José Hernández-Rodríguez,Maria Méndez,Maria Teresa Dordal,Maria Basagaña,Segundo Buján,Masato Yashiro,Tetsuo Kubota,Ryuji Koike,Naoko Akuta,Kumiko Shimoyama,Naomi Iwata,Megumu K. Saito,Osamu Ohara,Naotomo Kambe,Takahiro Yasumi,Kazushi Izawa,Tomoki Kawai,Toshio Heike,Jordi Yagüe,Ryuta Nishikomori,Juan I. Aróstegui +39 more
TL;DR: Somatic NLRP3 mosaicism underlying MWS is shown, probably representing a shared genetic mechanism in CAPS not restricted to CINCA syndrome, which had serious implications for gaining access to anti-interleukin 1 treatments under legal indication and for genetic counselling.
Journal ArticleDOI
DNA demethylation of inflammasome-associated genes is enhanced in patients with cryopyrin-associated periodic syndromes.
Roser Vento-Tormo,Damiana Álvarez-Errico,Antonio Garcia-Gomez,José Hernández-Rodríguez,Segundo Buján,Maria Basagaña,Maria Méndez,Jordi Yagüe,Manel Juan,Juan I. Aróstegui,Esteban Ballestar +10 more
TL;DR: This study is the first to demonstrate the involvement of DNA methylation–associated alterations in patients with monogenic autoinflammatory disease and opens up possibilities for novel clinical markers.