Felix Manstein

TL;DR: In this article, the authors generate complex, highly structured, three-dimensional heart-forming organoids by embedding human pluripotent stem cell aggregates in Matrigel followed by directed cardiac differentiation via biphasic WNT pathway modulation with small molecules.

TL;DR: In this paper, the authors combined instrumented stirred tank bioreactor (STBR) technology with the power of in silico process modeling to overcome substantial, hPSC-specific hurdles toward their mass production.

TL;DR: This process provides a useful advance for versatile applications of DE lineages, in particular for cell therapies and drug screening, and for bio-banking of differentiated derivatives from human pluripotent stem cells and embryonic stem cells.

TL;DR: In this paper, the authors investigated the effect of hypoxia on extracellular vesicles (EVs) in human induced pluripotent stem cells (iPSC) culture.

TL;DR: It is suggested that data-driven models and machine learning techniques can be employed using existing data for understanding and improving production of a specific cell type, which is potentially applicable to other lineages and critical for realization of their therapeutic applications.