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Alexandra Haase
Researcher at Hannover Medical School
Publications - 40
Citations - 1323
Alexandra Haase is an academic researcher from Hannover Medical School. The author has contributed to research in topics: Induced pluripotent stem cell & Reprogramming. The author has an hindex of 12, co-authored 34 publications receiving 1132 citations. Previous affiliations of Alexandra Haase include Hochschule Hannover.
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Journal ArticleDOI
Generation of Induced Pluripotent Stem Cells from Human Cord Blood
Alexandra Haase,Ruth Olmer,Kristin Schwanke,Stephanie Wunderlich,Sylvia Merkert,Christian Hess,Robert Zweigerdt,Ina Gruh,Johann Meyer,Stefan Wagner,Lars S. Maier,Dong Wook Han,Silke Glage,Konstantin Miller,Philipp Fischer,Hans R. Schöler,Ulrich Martin +16 more
TL;DR: The generation of human iPSCs from cord blood (CB) as a juvenescent cell source is reported, showing characteristics typical of embryonic stem cells and can be differentiated into derivatives of all three germ layers, including functional cardiomyocytes.
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Long term expansion of undifferentiated human iPS and ES cells in suspension culture using a defined medium
Ruth Olmer,Alexandra Haase,Sylvia Merkert,Wei Cui,Jiří Paleček,Jiří Paleček,Chen Ran,Chen Ran,Andreas Kirschning,Andreas Kirschning,Thomas Scheper,Thomas Scheper,Silke Glage,Konstantin Miller,Eliza Curnow,Eric Hayes,Ulrich Martin +16 more
TL;DR: The ability to expand HES / hiPS cells in a scalable suspension culture represents a critical step towards standardized production in stirred bioreactors.
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Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells
Sabine Klawitter,Nina V. Fuchs,Nina V. Fuchs,Kyle R. Upton,Martin Muñoz-Lopez,Ruchi Shukla,Jichang Wang,Marta García-Cañadas,Cesar Lopez-Ruiz,Daniel J. Gerhardt,Attila Sebe,Ivana Grabundzija,Sylvia Merkert,Patricia Gerdes,J. Andres Pulgarin,Anja Bock,Ulrike Held,Anett Witthuhn,Alexandra Haase,Balázs Sarkadi,Johannes Löwer,Ernst J. Wolvetang,Ulrich Martin,Zoltán Ivics,Zsuzsanna Izsvák,Jose L. Garcia-Perez,Geoffrey J. Faulkner,Gerald G. Schumann +27 more
TL;DR: In this article, the authors apply retrotransposon capture sequencing to eight human induced pluripotent stem cells (hiPSC) and three human embryonic stem cell (hESC) lines, revealing endogenous L1, Alu and SINE-VNTR-Alu (SVA) mobilization during reprogramming and stem cell cultivation.
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Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells
Henning Kempf,Ruth Olmer,Alexandra Haase,Annika Franke,Emiliano Bolesani,Kristin Schwanke,Diana Robles-Diaz,Michelle Coffee,Gudrun Göhring,Gerald Dräger,Gerald Dräger,Oliver Pötz,Thomas O. Joos,Erik Martinez-Hackert,Axel Haverich,Falk F. R. Buettner,Ulrich Martin,Robert Zweigerdt +17 more
TL;DR: Modulating the bulk cell density (BCD) deterministically alters anteroposterior patterning of primitive streak (PS)-like priming of hPSCs, demonstrating a decisive, functional role of the BCD and showing its utility as a method to control lineage-specific differentiation.
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Primate iPS cells as tools for evolutionary analyses
Stephanie Wunderlich,Martin Kircher,Beate Vieth,Alexandra Haase,Sylvia Merkert,Jennifer Beier,Gudrun Göhring,Silke Glage,Axel Schambach,Eliza Curnow,Svante Pääbo,Ulrich Martin,Wolfgang Enard +12 more
TL;DR: Induced pluripotent stem cells from non-human primates reveal insights into general primate gene expression evolution and should provide a rich source to identify conserved and species-specific gene expression patterns for cellular phenotypes.