There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.

Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

I and i

다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

Deposits of clastic carbonate-dominated (calciclastic) sedimentary slope systems in the rock record have been identified mostly as linearly-consistent carbonate apron deposits, even though most ancient clastic carbonate slope deposits fit the submarine fan systems better. Calciclastic submarine fans are consequently rarely described and are poorly understood. Subsequently, very little is known especially in mud-dominated calciclastic submarine fan systems. Presented in this study are a sedimentological core and petrographic characterisation of samples from eleven boreholes from the Lower Carboniferous of Bowland Basin (Northwest England) that reveals a >250 m thick calciturbidite complex deposited in a calciclastic submarine fan setting. Seven facies are recognised from core and thin section characterisation and are grouped into three carbonate turbidite sequences. They include: 1) Calciturbidites, comprising mostly of highto low-density, wavy-laminated bioclast-rich facies; 2) low-density densite mudstones which are characterised by planar laminated and unlaminated muddominated facies; and 3) Calcidebrites which are muddy or hyper-concentrated debrisflow deposits occurring as poorly-sorted, chaotic, mud-supported floatstones. These

Phd by thesis

https://pubs.rsc.org/en/content/articlepdf/2019/NP/C8NP00092A

Marine natural products.

Polydopamine and Its Derivative Materials: Synthesis and Promising Applications in Energy, Environmental, and Biomedical Fields

C48H74F6N6O32V10, monoclinic, P121/a1 (no. 14), a = 10.000(1) Å, b = 18.713(1) Å, c = 19.070(1) Å, 3 = 101.06(1)°, V = 3502.3 Å, Z = 2, Rgt(F) = 0.032, wRref(F) = 0.080, T = 293 K. Source of material Sodium vanadate (1.120 g, 10mol) was dissolved in water (30ml) and pHwas adjusted at 7.4 by addition of 1NHCl. Then 4-fluorophenylethylammonium (1.053 g, 6mol) hydrochloride was added, which induced the precipitation of a solid. This solid was filtered under vacuum and dried over P2O5 in a vacuum oven at 30 °C to obtain the title compound. Afterwards, a saturated solution of the title compound in water or H2O was prepared, and evaporated at room temperature to obtain orange needles. Elemental analysis – found: C, 31.74%;H, 4.02%;N, 4.65%;O, 34.31 %; V, 25.42 %; calc. for C43H74N5O35V8: C, 32.06 %; H, 3.70 %; F, 6.34 %; N, 4.67 %; O, 24.91 %; V, 28.32 %. HNMR, C NMR and V NMR data are available in the CIF. Experimental details 21 H atoms were located from a difference synthesis and refined with overall isotropic temperature factors and 16 H atoms were not found, fromwhich 14 were computed and refined using a riding model, with isotropic displacement parameters equal to 1.2 times the equivalent temperature factors of the atoms which are linked.The twoHatomsattached towaterO15werenot analyzed. Discussion A combination formed by vanadium compounds and amines of the semicarbazide-sensitive amine oxidase (SSAO) substrate group has been described [1,2] to show a potent synergic insulin effect. The use of a single compound containing vanadium and small amine organic molecule is required from a pharmaceutical point of view. The preparation of these types of salts have been previously reported [3-6]. Our group is interested in preparing arylalkylamine decavanadate(V) salts and to test them as insulinomimetic agents. As example, the salt hexaquabis(benzylammonium) decavanadate(V) dihydrate (C7NH10)6[V10O28] · 2H2O was recently synthesized and characterized chemically and biologically [7]. The crystal structure of the title compound reveals the presence of two water molecules, three (4-fluorophenyl)ethylammonium cations (C8H11FN) and one half of the decavanadate anion V10O28 in the asymmetric unit (figure, top). The bond angles and distances for the V10O28 unit shows that the geometry is quite similar to that of decavanadate salts reported in other studies. In the V10O28, each VO6 octahedron is considerably disZ. Kristallogr. NCS 223 (2008) 45-47 / DOI 10.1524/ncrs.2008.0022 45 © by Oldenbourg Wissenschaftsverlag, München

Crystal structure of hexakis(4-fluorophenylethylammonium)decavanadate( V) tetrahydrate, (C8H11FN)6[V10O28] · 4H2O

Disulfide Bonded Cyclic Peptide Dimers and Trimers: An Easy Entry to High Symmetry Peptide Frameworks

The thiouronium salts S-(1-oxido-2-pyridinyl)-1,1,3,3-tetramethylthiouronium hexafluorophosphate (HOTT) and tetrafluoroborate (TOTT), and S-(1-oxido-2-pyridinyl)-1,3-dimethyl-1,3-trimethylenethiouronium hexafluorophosphate (HODT) and tetrafluoroborate (TODT), prepared from 2-mercaptopyridine-1-oxide and 1,1,3,3-tetramethylurea (TMU) or 1,3-dimethylpropyleneurea (DMPU), have been employed as reagents in solution and solid-phase peptide coupling chemistry. Furthermore, 2-mercaptopyridine-1-oxide has been employed as racemization-reducing additive combined with the new thiouronium salts and other frequently used peptide coupling reagents such as DCC or TBTU.

2‐Mercaptopyridine‐1‐oxide‐based Peptide Coupling Reagents.

Peptides are particularly attractive as molecular building blocks in the bottom-up fabrication of supramolecular structures based on self-assembly and have potential in many important applications in the fields of biotechnology and bioengineering. In the first part of this critical review the main categories of peptide-based amphiphiles will be discussed by showing some relevant examples, which demonstrate the importance of amphiphilic peptides as molecular building blocks for nanostructures. In the second part of this review we will review the cross-disciplinary role of peptide-based supramolecular nanoarchitectures ranging from chemistry to biology, medicine, materials science, and engineering through discussing several examples of applied nanomaterials (216 references).

Amphiphilic Peptides and Their Cross-Disciplinary Role as Building Blocks for Nanoscience

applies pressure on the conformational ensemble of thepeptide to select its complementary conformation. Given theflexible nature of the peptides’ modular architecture, abioactive sequence must often be primed for recognition ofits target to achieve high binding affinity or specificity. Forrational peptide design, cyclization or structure-inducingresidues have been successfully used to accomplish ligandpreorganization.

Fernando Albericio

Papers

Crystal structure of hexakis(4-fluorophenylethylammonium)decavanadate( V) tetrahydrate, (C8H11FN)6[V10O28] · 4H2O

Disulfide Bonded Cyclic Peptide Dimers and Trimers: An Easy Entry to High Symmetry Peptide Frameworks

2‐Mercaptopyridine‐1‐oxide‐based Peptide Coupling Reagents.

Amphiphilic Peptides and Their Cross-Disciplinary Role as Building Blocks for Nanoscience

Amide-to-Ester Substitution Allows Fine-Tuning of the Cyclopeptide