F
Fernando Albericio
Researcher at University of KwaZulu-Natal
Publications - 1012
Citations - 29912
Fernando Albericio is an academic researcher from University of KwaZulu-Natal. The author has contributed to research in topics: Peptide synthesis & Solid-phase synthesis. The author has an hindex of 76, co-authored 965 publications receiving 26146 citations. Previous affiliations of Fernando Albericio include University of Barcelona & University of Chile.
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Journal ArticleDOI
p‐Nitrobenzyloxycarbonyl (pNZ) as a Temporary Nα‐Protecting Group in Orthogonal Solid‐Phase Peptide Synthesis – Avoiding Diketopiperazine and Aspartimide Formation
TL;DR: In this paper, Nitrobenzyloxycarbonyl (pNZ) was used as a temporary protecting group for α-amino functionalities in solid-phase peptide synthesis.
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Green Solid-Phase Peptide Synthesis (GSPPS) 3. Green Solvents for Fmoc Removal in Peptide Chemistry
Yahya E. Jad,Thavendran Govender,Hendrik G. Kruger,Ayman El-Faham,Ayman El-Faham,Beatriz G. de la Torre,Fernando Albericio,Fernando Albericio +7 more
TL;DR: It was found that γ-valerolactone can replace DMF for Fmoc removal steps during SPPS on both resins, PS or Chem Matrix, and deletion peptides and Nα-Fmoc terminal peptides were observed upon TFA cleavage of the peptide from the resin duringSPPS of a challenging aggregated peptide.
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The first total synthesis of the cyclodepsipeptide pipecolidepsin A
Marta Pelay-Gimeno,Yésica García-Ramos,María J. Martín,Jan Spengler,José Manuel Molina-Guijarro,Simon Munt,Andrés Francesch,Carmen Cuevas,Judit Tulla-Puche,Fernando Albericio +9 more
TL;DR: The first total synthesis of a D-allo-AHDMHA-containing peptide, pipecolidepsin A, is described, allowing chemical structure validation of the natural product and providing a robust synthetic strategy to access other members of the relevant head-to-side-chain family in a straightforward manner.
Journal ArticleDOI
Isololiolide, a carotenoid metabolite isolated from the brown alga Cystoseira tamariscifolia, is cytotoxic and able to induce apoptosis in hepatocarcinoma cells through caspase-3 activation, decreased Bcl-2 levels, increased p53 expression and PARP cleavage.
Catarina Vizetto-Duarte,Luísa Custódio,Katkam N. Gangadhar,João Henrique G. Lago,Catarina Dias,Ana M. Matos,Nuno R. Neng,José M.F. Nogueira,Luísa Barreira,Fernando Albericio,Amélia P. Rauter,João Varela +11 more
TL;DR: Isololiolide isolated from C. tamariscifolia is able to exert a selective cytotoxic activity on hepatocarcinoma HepG2 cells as well as induce apoptosis through the modulation of apoptosis-related proteins.
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Solid-Phase Total Synthesis of Trunkamide A1
TL;DR: The solid-phase total synthesis of trunkamide A, currently in preclinical trials, is presented, which contains a thiazoline heterocycle and two residues of Ser and Thr with the hydroxy function modified as reverse prenyl (rPr).