Fernando Albericio

TL;DR: MALDI-TOF analysis was a useful analytical technique to determine the phenomenon of base-catalyzed elimination of the sulfhydryl-protected side-chain to afford the dehydroalanine derivative followed by a nucleophilic addition to the alkene.

TL;DR: The results reveal that after mono N-methylation of the peptide backbone, ΔGsolv becomes more negative (more water soluble) while polarizability and dipole moment are also increased, and natural atomic charges derived by natural bond orbital (NBO) analysis of N, C, and O atoms involved in amide functional group become more positive/(less negative) after N- methylation.

TL;DR: Convergent solid-phase peptide synthesis (CSPPS) involves solidphase synthesis of protected peptides (these must retain the protecting groups of the N α -amino and the side-chain functions after cleavage from the resin), purification and characterization of the protected peptide segments, and their solid- phase coupling.

TL;DR: It is shown that the MA16-encoded protein binds preferentially to uridine- and guanosine-rich RNAs, suggesting a likely role for this protein in RNA metabolism during late embryogenesis and in the stress response.

TL;DR: A series of short tryptophan-phenylalanine peptides containing an iodo substituent on the phenyl ring was subjected to Pd-catalyzed CH activation reactions to give the corresponding aryl-indole coupled products.