Fernando Macian

TL;DR: This Review focuses on the recent advances in the understanding of the regulation, mechanism of action and functions of NFAT proteins in T cells.

TL;DR: Pharmacological interference with the NFAT:AP-1 interaction may be useful in selective manipulation of the immune response, and Balanced activation of NFAT and AP-1 is known to be required for productive immune responses, but the role of NFT-1 interactions in other cell types and biological processes remains to be understood.

TL;DR: It is shown that the Ca2+-regulated transcription factor NFAT has an integral role in both aspects of lymphocyte function and in the absence of AP-1, NFAT imposes a genetic program of lymphocytes anergy that counters the program of productive activation mediated by the cooperative NFAT:AP-1 complex.

TL;DR: The data point to a biphasic process in which cytokine-driven signaling pathways maintain and reinforce chromatin structural changes initiated by the TCR, which ensures that cytokine genes remain accessible to the relevant transcription factors and promotes functional cooperation of the inducible transcription factor NFAT with lineage-specific transcription factors such as GATA-3 and T-bet.

TL;DR: A complex molecular program that links gene transcription induced by calcium and calcineurin to a paradoxical impairment of signal transduction in anergic T cells is defined.