Fernando Pelaez

TL;DR: The evaluation of over 200,000 extracts originating from more than 50,000 microbial strains equally represented by fungi and actinomycetes led to the discovery of 24 novel classes of chemically diverse natural product inhibitors of HIV-1 integrase, representing a wide variety of classes with molecular weights ranging from 180-1,663 Da and HIV- 1 integrase-inhibitory activity IC 5 0 values ranging from 50 nM to > 100 μM.

TL;DR: A Simple Tandem Repeat sequence of 11 nucleotides has been found in the ITS1 region of the rDNA of members of Order Xylariales, and it is shown that the presence of this sequence increases the normal rate of divergence in theITS1 of the Xylariaes.

TL;DR: The genetic relatedness among 29 collections belonging to 20 of the most common species of genus Amanita in the Iberian Peninsula have been studied by means of restriction analysis of the amplified ITS1–5.8S-ITS2 region of rDNA, finding that this technique could be useful to identify and characterize isolates from Amanita species.

TL;DR: Placement of acetyl groups along the alkyl chain modulated the potency of the bis-tetrahydrofuranic acetogenins and could be important for future utilization of these compounds as chemotherapeutic agents.

TL;DR: Cytosporin A, B and C, three antagonists of [125I]-angiotensin II binding to rat adrenal glands were discovered in fermentations of an endophytic Cytospora sp.