Fernando Pelaez

TL;DR: Three new diphenyl ethers, barceloneic acids A, B, and barcel oneic lactone were isolated from a fermentation extract of a fungus of the genus Phoma and the effect of these compounds on the inhibition of farnesyl-protein transferase (FPTase) was evaluated and results are presented.

TL;DR: An extract of Geomyces pannorum was identified as providing increased activity against the sensitized strain as compared with the wild-type control, andBioassay-guided isolation of the active component from this fungal extract provided a new cis-decalin secondary metabolite, which is named pannomycin.

TL;DR: Screening of microbial extracts followed by bioassay-guided isolation led to the discovery of a natural hinnuliquinone, a C(2)-symmetric bis-indolyl quinone natural product that inhibited the wild-type and a clinically resistant (A44) strain of HIV-1 protease.

TL;DR: Random amplified polymorphic DNA (RAPD) profiles were used to analyse the infraspecific variability within the populations of the two dominant species, Heliscus lugdunensis and Articulospora tetracladia, suggesting the presence of a relatively stable pool of fungal genotypes colonizing the plant substrates along the stream.

TL;DR: Ten different families of compounds are identified, all of which selectively inhibit FPTase with a variety of mechanisms, which originated from the fermentations of a number of microorganisms, either actinomycetes or fungi, isolated from different substrates collected in tropical and temperate areas.