F
Fernando Pelaez
Researcher at Merck & Co.
Publications - 124
Citations - 7806
Fernando Pelaez is an academic researcher from Merck & Co.. The author has contributed to research in topics: Integrase & Farnesyl Protein Transferase. The author has an hindex of 41, co-authored 124 publications receiving 7350 citations. Previous affiliations of Fernando Pelaez include Autonomous University of Madrid.
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Journal ArticleDOI
Isolation, structure, and absolute stereochemistry of platensimycin, a broad spectrum antibiotic discovered using an antisense differential sensitivity strategy.
Sheo B. Singh,Hiranthi Jayasuriya,John G. Ondeyka,Kithsiri Herath,Chaowei Zhang,Deborah L. Zink,Nancy N. Tsou,Richard G. Ball,Angela Basilio,Olga Genilloud,Maria Teresa Diez,Francisca Vicente,Fernando Pelaez,Katherine Young,Jun Wang +14 more
TL;DR: It was determined that potential reactivity of the enone moiety does not play a key role in the biological activity of platensimycin and cyclohexenone ring conformation renders for the stronger binding interaction with the enzyme.
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Discovery of FabH/FabF Inhibitors from Natural Products
Katherine Young,Hiranthi Jayasuriya,John G. Ondeyka,Kithsiri Herath,Chaowei Zhang,Srinivas Kodali,Andrew Galgoci,Ronald E. Painter,Vickie Brown-Driver,Robert T. Yamamoto,Lynn L. Silver,Yingcong Zheng,Judith I. Ventura,Janet M. Sigmund,Sookhee Ha,Angela Basilio,Francisca Vicente,José R. Tormo,Fernando Pelaez,Phil Youngman,Doris F. Cully,John F. Barrett,Dennis M. Schmatz,Sheo B. Singh,Jun Wang +24 more
TL;DR: The mechanism of decreased target protein production by expression of antisense RNA was investigated using Northern blotting and revealed that the antisenseRNA acts posttranscriptionally by targeting mRNA, leading to 5′ mRNA degradation.
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Screening of 68 species of basidiomycetes for enzymes involved in lignin degradation
TL;DR: A survey for enzymes involved in lignin degradation was carried out from 90 strains of 68 species of different groups of basidiomycetes, and MnP seemed to be restricted to species of Aphyllophorales, with the exception of the tremellaceous fungus Exidia glandulosa.
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The farnesoid X receptor controls gene expression in a ligand- and promoter-selective fashion
Jane-L. Lew,Annie Zhao,Jinghua Yu,Li Huang,Nuria de Pedro,Fernando Pelaez,Samuel D. Wright,Jisong Cui +7 more
TL;DR: It is shown that the binding of each bile acid results in a different FXR conformations, which in turn differentially regulates expression of individual FXR targets.
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Isolation and Structure of Platencin: A FabH and FabF Dual Inhibitor with Potent Broad-Spectrum Antibiotic Activity
Hiranthi Jayasuriya,Kithsiri Herath,Chaowei Zhang,Deborah L. Zink,Angela Basilio,Olga Genilloud,Maria Teresa Diez,Francisca Vicente,Ignacio González,Oscar Salazar,Fernando Pelaez,Richard D. Cummings,Sookhee Ha,Jun Wang,Sheo B. Singh +14 more