F
Fernando Pelaez
Researcher at Merck & Co.
Publications - 124
Citations - 7806
Fernando Pelaez is an academic researcher from Merck & Co.. The author has contributed to research in topics: Integrase & Farnesyl Protein Transferase. The author has an hindex of 41, co-authored 124 publications receiving 7350 citations. Previous affiliations of Fernando Pelaez include Autonomous University of Madrid.
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Journal ArticleDOI
Molecular phylogenetic studies on the Diatrypaceae based on rDNA-ITS sequences.
Francisco Javier Acero,Vicente González,Javier Sánchez-Ballesteros,Víctor J. Rubio,Julia Checa,Gerald F. Bills,Oscar Salazar,Gonzalo Platas,Fernando Pelaez +8 more
TL;DR: The need to revise many of the concepts usually applied to the classification of members of the Diatrypaceae family is suggested, suggesting that the multisporate asci character has appeared several times during the evolution of the group.
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PAP Inhibitor with In Vivo Efficacy Identified by Candida albicans Genetic Profiling of Natural Products
Bo Jiang,Deming Xu,John J. Allocco,Craig A. Parish,John Davison,Karynn Veillette,Susan Sillaots,Wenqi Hu,Roberto Rodriguez-Suarez,Steve Trosok,Li Zhang,Yang Li,Fariba Rahkhoodaee,Tara Ransom,Nick Martel,Hao Wang,Daniel Gauvin,Judyann Wiltsie,Douglas Wisniewski,Scott P. Salowe,Jennifer Nielsen Kahn,Ming Jo Hsu,Robert A. Giacobbe,George K. Abruzzo,Amy M. Flattery,Charles Gill,Phil Youngman,Kenneth E. Wilson,Gerald F. Bills,Gonzalo Platas,Fernando Pelaez,Maria Teresa Diez,Sarah Kauffman,Jeff Becker,Guy H. Harris,Paul A. Liberator,Terry Roemer +36 more
TL;DR: Parnafungin displays potent and broad spectrum activity against diverse, clinically relevant fungal pathogens and reduces fungal burden in a murine model of disseminated candidiasis, and mechanism-of-action determination of crude fermentation extracts by chemical-genetic profiling brings a powerful strategy to natural-product-based drug discovery.
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Isolation and structure elucidation of parnafungins, antifungal natural products that inhibit mRNA polyadenylation.
Craig A. Parish,Scott K. Smith,Kathleen Calati,Deborah L. Zink,Kenneth E. Wilson,Terry Roemer,Bo Jiang,Deming Xu,Gerald F. Bills,Gonzalo Platas,Fernando Pelaez,Maria Teresa Diez,Nancy N. Tsou,Arlene E. Mckeown,Richard G. Ball,Mary Ann Powles,Lai Yeung,Paul A. Liberator,Guy H. Harris +18 more
TL;DR: Parnafungins demonstrated broad spectrum antifungal activity with no observed activity against gram-positive or gram-negative bacteria.
Journal Article
Molecular phylogenetic studies within the Xylariaceae based on ribosomal DNA sequences
TL;DR: The phylogenetic reconstructions showed a reasonable degree of correlation between the sequence data and the proposed morphological classification schemes only for some genera within the family, suggesting the need for further revision of the generic concepts and diagnostic characters within the Xylariaceae.
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Identification of an endophytic Nodulisporium sp. from Quercus ilex in central Spain as the anamorph of Biscogniauxia mediterranea by rDNA sequence analysis and effect of different ecological factors on distribution of the fungus
TL;DR: Tissue preference analysis revealed that this fungal species is exclusively located in bark, being absent from xylem of living twigs, and the relative abundance of the fungus in decaying twigs was remarkably higher than in healthy twigs.