F
Fernando Pelaez
Researcher at Merck & Co.
Publications - 124
Citations - 7806
Fernando Pelaez is an academic researcher from Merck & Co.. The author has contributed to research in topics: Integrase & Farnesyl Protein Transferase. The author has an hindex of 41, co-authored 124 publications receiving 7350 citations. Previous affiliations of Fernando Pelaez include Autonomous University of Madrid.
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Journal ArticleDOI
Production of a family of kinase-inhibiting lactones from fungal fermentations
Anne W. Dombrowski,Rosalind G. Jenkins,Susan L. Raghoobar,Gerald F. Bills,Jon D. Polishook,Fernando Pelaez,Bruce Burgess,Annie Zhao,Leeyuan Huang,Yan Zhang,Michael A. Goetz +10 more
TL;DR: During the course of the screening for natural products from fungi, extracts of several cultures were found to make a family of related resorcylic acid lactone compounds, which are potent inhibitors of MEK kinase.
Journal ArticleDOI
Monosporascus ibericus sp. nov., an endophytic ascomycete from plants on saline soils, with observations on the position of the genus based on sequence analysis of the 18S rDNA
Javier Collado,Antonio Gonzalez,Gonzalo Platas,Alberto M. Stchigel,Josep Guarro,Fernando Pelaez +5 more
TL;DR: A phylogenetic study based on the sequences of the 18S rDNA did not allow us to assess clearly the taxonomic position of the genus Monosporascus, although the results indicated the genus might have affinities to the Xylariales rather than to the Sordariales.
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Fusidienol A: A Novel Ras Farnesyl-Protein Transferase Inhibitor from Phoma sp.
Suresh B. Singh,Richard G. Ball,Deborah L. Zink,Richard L. Monaghan,Jon D. Polishook,Manuel Sanchez,Fernando Pelaez,Keith C. Silverman,Russell B. Lingham +8 more
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The discovery of moriniafungin, a novel sordarin derivative produced by Morinia pestalozzioides
Angela Basilio,Michael C. Justice,Georgianna Harris,Gerald F. Bills,Javier Collado,M. de la Cruz,Maria Teresa Diez,Pilar Hernández,Paul A. Liberator,J. Nielsen Kahn,Fernando Pelaez,Gonzalo Platas,Dennis M. Schmatz,Mythili S. Shastry,José R. Tormo,Gregers R. Andersen,Francisca Vicente +16 more
TL;DR: Miniafungin has the broadest antifungal spectrum and most potent activity of any natural sordarin analog identified to date and was shown to inhibit in vitro translation in the chimeric S. cerevisae strains at levels consistent with the observed IC(50).
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Development of an HTS Assay for the Search of Anti-influenza Agents Targeting the Interaction of Viral RNA with the NS1 Protein
TL;DR: The hypothesis that the binding of NS1 protein to viral RNA (vRNA) could constitute a novel target for the search of anti-influenza drugs is supported.